Growth control of sessile microbubbles in PDMS devices

Andreas Volk, Massimiliano Rossi, Christian J. Kähler, Sascha Hilgenfeldt, Alvaro Marin

Research output: Contribution to journalArticlepeer-review


In a microfluidic environment, the presence of bubbles is often detrimental to the functionality of the device, leading to clogging or cavitation, but microbubbles can also be an indispensable asset in other applications such as microstreaming. In either case, it is crucial to understand and control the growth or shrinkage of these bodies of air, in particular in common soft-lithography devices based on polydimethylsiloxane (PDMS), which is highly permeable to gases. In this work, we study the gas transport into and out of a bubble positioned in a microfluidic device, taking into account the direct gas exchange through PDMS as well as the transport of gas through the liquid in the device. Hydrostatic pressure regulation allows for the quantitative control of growth, shrinkage, or the attainment of a stable equilibrium bubble size. We find that the vapor pressure of the liquid plays an important role for the balance of gas transport, accounting for variability in experimental conditions and suggesting additional means of bubble size control in applications.

Original languageEnglish (US)
Pages (from-to)4607-4613
Number of pages7
JournalLab on a chip
Issue number24
StatePublished - Oct 14 2015

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • General Chemistry
  • Biomedical Engineering


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