Green microfluidics made of corn proteins

Austin Hsiao, Jarupat Luecha, Jozef Kokini, Gang Logan Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Petroleum-based polymer such as Poly(dimethylsiloxane) has been widely used to make mesoscale and microscale fluidic devices. The main drawback of such devices in disposable applications is the potential environmental pollution since they are not biodegradable. Biodegradable microfluidic devices have been fabricated out of zein, a prolamin protein found in corn, that can be utilized as disposable health and environmental-friendly micro-chips. Using stereo lithography and soft lithography, micro-chambers and micro-channels features have been replicated on zein films and enclosed zein microfluidic devices are created by bonding to glass substrate using a simple vapor-deposition method. The bonding strength of the zein microfluidic devices has been found to exceed the tensile strength of the zein film and hydraulic pressure, and fluid flow through large-area complex microfluidic designs shows no leakage or distortion. High optical clarity and fluorescent imaging in the zein microfluidic devices are demonstrated by visualizing micro-particles and Rhodamine B. Zein microfluidic devices enable truly disposable microfluidics with intrinsic biocompatibility and biodegradability that can be fabricated using existing techniques.

Original languageEnglish (US)
Title of host publication33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Pages8400-8403
Number of pages4
DOIs
StatePublished - Dec 26 2011
Event33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 - Boston, MA, United States
Duration: Aug 30 2011Sep 3 2011

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
CountryUnited States
CityBoston, MA
Period8/30/119/3/11

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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  • Cite this

    Hsiao, A., Luecha, J., Kokini, J., & Liu, G. L. (2011). Green microfluidics made of corn proteins. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 (pp. 8400-8403). [6092072] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/IEMBS.2011.6092072