Graphene Hybrid Tough Hydrogels with Nanostructures for Tissue Regeneration

Yonghyun Gwon, Sangbae Park, Woochan Kim, Sunho Park, Harshita Sharma, Hoon Eui Jeong, Hyunjoon Kong, Jangho Kim

Research output: Contribution to journalArticlepeer-review


Over the past few decades, hydrogels have attracted considerable attention as promising biomedical materials. However, conventional hydrogels require improved mechanical properties, such as brittleness, which significantly limits their widespread use. Recently, hydrogels with remarkably improved toughness have been developed; however, their low biocompatibility must be addressed. In this study, we developed a tough graphene hybrid hydrogel with nanostructures. The resultant hydrogel exhibited remarkable mechanical properties while representing an aligned nanostructure that resembled the extracellular matrix of soft tissue. Owing to the synergistic effect of the topographical properties, and the enhanced biochemical properties, the graphene hybrid hydrogel had excellent stretchability, resilience, toughness, and biocompatibility. Furthermore, the hydrogel displayed outstanding tissue regeneration capabilities (e.g., skin and tendons). Overall, the proposed graphene hybrid tough hydrogel may provide significant insights into the application of tough hydrogels in tissue regeneration.

Original languageEnglish (US)
Pages (from-to)2188-2195
Number of pages8
JournalNano letters
Issue number7
StatePublished - Feb 21 2024


  • Graphene
  • Nanostructure
  • Skin regeneration
  • Tendon regeneration
  • Tough hydrogels

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanical Engineering


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