Graphene-DNAzyme junctions: A platform for direct metal ion detection with ultrahigh sensitivity

Li Gao, Le Le Li, Xiaolong Wang, Peiwen Wu, Yang Cao, Bo Liang, Xin Li, Yuanwei Lin, Yi Lu, Xuefeng Guo

Research output: Contribution to journalArticlepeer-review

Abstract

Many metal ions are present in biology and in the human body in trace amounts. Despite numerous efforts, metal sensors with ultrahigh sensitivity (<a few picomolar) are rarely achieved. Here, we describe a platform method that integrates a Cu2+-dependent DNAzyme into graphene-molecule junctions and its application for direct detection of paramagnetic Cu2+ with femtomolar sensitivity and high selectivity. Since DNAzymes specific for other metal ions can be obtained through in vitro selection, the method demonstrated here can be applied to the detection of a broad range of other metal ions.

Original languageEnglish (US)
Pages (from-to)2469-2473
Number of pages5
JournalChemical Science
Volume6
Issue number4
DOIs
StatePublished - Apr 1 2015

ASJC Scopus subject areas

  • Chemistry(all)

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