Gonadotropin-releasing hormone (GnRH) analogues and the ovary: Do GnRH antagonists destroy primordial follicles?

Rupesh K. Gupta; Jodi A. Flaws

doi:10.1016/j.fertnstert.2005.01.089

Gonadotropin-releasing hormone (GnRH) analogues and the ovary: Do GnRH antagonists destroy primordial follicles?

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Abstract

The study by Danforth et al. shows that gonadotropin-releasing hormone (GnRH) antagonists do not protect ovarian follicles from chemotherapy-induced damage and that GnRH antagonists alone reduce primordial follicle numbers in mice. This article discusses the strengths and limitations of the study by Danforth et al., as well as the potential mechanism of action of GnRH antagonists according to the literature.

Original language	English (US)
Pages (from-to)	1339-1342
Number of pages	4
Journal	Fertility and Sterility
Volume	83
Issue number	5
DOIs	https://doi.org/10.1016/j.fertnstert.2005.01.089
State	Published - May 2005
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/j.fertnstert.2005.01.089

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abstract = "The study by Danforth et al. shows that gonadotropin-releasing hormone (GnRH) antagonists do not protect ovarian follicles from chemotherapy-induced damage and that GnRH antagonists alone reduce primordial follicle numbers in mice. This article discusses the strengths and limitations of the study by Danforth et al., as well as the potential mechanism of action of GnRH antagonists according to the literature.",

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Gonadotropin-releasing hormone (GnRH) analogues and the ovary: Do GnRH antagonists destroy primordial follicles?

Abstract

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