Gonadotropin receptors

Kirsten S. Eckstrum, Lori T. Raetzman

Research output: Chapter in Book/Report/Conference proceedingChapter


The gonadotropin receptors luteinizing hormone receptor and follicle stimulating hormone receptor are the main way the hormonal signals luteinizing hormone and follicle stimulating hormone communicate to the ovary. This article covers the gene and protein structure information about the receptors. It also illustrates the signaling pathways used by these two G-protein coupled receptors both generally and with references to functions within ovarian theca and granulosa cells. Finally, human mutations in these receptors that impact fertility are described.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Reproduction
Number of pages5
ISBN (Electronic)9780128151457
StatePublished - Jan 1 2018


  • Cyclic AMP (cAMP)
  • Follicle stimulating hormone (FSH)
  • Follicle stimulating hormone receptor (FSHR)
  • Folliculogenesis
  • G protein coupled receptor
  • Gonadotropin
  • Hormones
  • Hypogonadotropic hypogonadism
  • Luteinizing hormone (LH)
  • Luteinizing hormone receptor (LHR)
  • Mitogen-activated protein kinases (MAPK)
  • Steroidogenic acute regulatory protein (STAR)

ASJC Scopus subject areas

  • General Medicine


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