Gold nanorods: Their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions

Alaaldin M. Alkilany, Lucas B. Thompson, Stefano P. Boulos, Patrick N. Sisco, Catherine J. Murphy

Research output: Contribution to journalReview article

Abstract

Gold nanorods have promising applications in the fields of drug delivery and photothermal therapy. These promises arise from the nanorods' unique optical and photothermal properties, the availability of synthetic protocols that can tune the size and shape of the particles, the ability to modify the surface and conjugate drugs/molecules to the nanorods, and the relative biocompatibility of gold nanorods. In this review, current progress in using gold nanorods as phototherapeutic agents and as drug delivery vehicles is summarized. Issues of dosage, toxicity and biological interactions at three levels (biological media alone; cells; whole organisms) are discussed, concluding with recommendations for future work in this area.

Original languageEnglish (US)
Pages (from-to)190-199
Number of pages10
JournalAdvanced Drug Delivery Reviews
Volume64
Issue number2
DOIs
StatePublished - Feb 1 2012

Fingerprint

Nanotubes
Gold
Pharmaceutical Preparations
Therapeutics
Particle Size

Keywords

  • Bioconjugation
  • Cellular uptake
  • Drug delivery
  • Gold nanorods
  • Photothermal therapy
  • Surface modification
  • Toxicity

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Gold nanorods : Their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions. / Alkilany, Alaaldin M.; Thompson, Lucas B.; Boulos, Stefano P.; Sisco, Patrick N.; Murphy, Catherine J.

In: Advanced Drug Delivery Reviews, Vol. 64, No. 2, 01.02.2012, p. 190-199.

Research output: Contribution to journalReview article

Alkilany, Alaaldin M. ; Thompson, Lucas B. ; Boulos, Stefano P. ; Sisco, Patrick N. ; Murphy, Catherine J. / Gold nanorods : Their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions. In: Advanced Drug Delivery Reviews. 2012 ; Vol. 64, No. 2. pp. 190-199.
@article{942cf551eb6a427390d16d9c847ed9a4,
title = "Gold nanorods: Their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions",
abstract = "Gold nanorods have promising applications in the fields of drug delivery and photothermal therapy. These promises arise from the nanorods' unique optical and photothermal properties, the availability of synthetic protocols that can tune the size and shape of the particles, the ability to modify the surface and conjugate drugs/molecules to the nanorods, and the relative biocompatibility of gold nanorods. In this review, current progress in using gold nanorods as phototherapeutic agents and as drug delivery vehicles is summarized. Issues of dosage, toxicity and biological interactions at three levels (biological media alone; cells; whole organisms) are discussed, concluding with recommendations for future work in this area.",
keywords = "Bioconjugation, Cellular uptake, Drug delivery, Gold nanorods, Photothermal therapy, Surface modification, Toxicity",
author = "Alkilany, {Alaaldin M.} and Thompson, {Lucas B.} and Boulos, {Stefano P.} and Sisco, {Patrick N.} and Murphy, {Catherine J.}",
year = "2012",
month = "2",
day = "1",
doi = "10.1016/j.addr.2011.03.005",
language = "English (US)",
volume = "64",
pages = "190--199",
journal = "Advanced Drug Delivery Reviews",
issn = "0169-409X",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Gold nanorods

T2 - Their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions

AU - Alkilany, Alaaldin M.

AU - Thompson, Lucas B.

AU - Boulos, Stefano P.

AU - Sisco, Patrick N.

AU - Murphy, Catherine J.

PY - 2012/2/1

Y1 - 2012/2/1

N2 - Gold nanorods have promising applications in the fields of drug delivery and photothermal therapy. These promises arise from the nanorods' unique optical and photothermal properties, the availability of synthetic protocols that can tune the size and shape of the particles, the ability to modify the surface and conjugate drugs/molecules to the nanorods, and the relative biocompatibility of gold nanorods. In this review, current progress in using gold nanorods as phototherapeutic agents and as drug delivery vehicles is summarized. Issues of dosage, toxicity and biological interactions at three levels (biological media alone; cells; whole organisms) are discussed, concluding with recommendations for future work in this area.

AB - Gold nanorods have promising applications in the fields of drug delivery and photothermal therapy. These promises arise from the nanorods' unique optical and photothermal properties, the availability of synthetic protocols that can tune the size and shape of the particles, the ability to modify the surface and conjugate drugs/molecules to the nanorods, and the relative biocompatibility of gold nanorods. In this review, current progress in using gold nanorods as phototherapeutic agents and as drug delivery vehicles is summarized. Issues of dosage, toxicity and biological interactions at three levels (biological media alone; cells; whole organisms) are discussed, concluding with recommendations for future work in this area.

KW - Bioconjugation

KW - Cellular uptake

KW - Drug delivery

KW - Gold nanorods

KW - Photothermal therapy

KW - Surface modification

KW - Toxicity

UR - http://www.scopus.com/inward/record.url?scp=84858614944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858614944&partnerID=8YFLogxK

U2 - 10.1016/j.addr.2011.03.005

DO - 10.1016/j.addr.2011.03.005

M3 - Review article

C2 - 21397647

AN - SCOPUS:84858614944

VL - 64

SP - 190

EP - 199

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

IS - 2

ER -