Gold nanoparticles: Interesting optical properties and recent applications in cancer diagnostics and therapy

Xiaohua Huang, Prashant K. Jain, Ivan H. El-Sayed, Mostafa A. El-Sayed

Research output: Contribution to journalReview article

Abstract

Recent years have seen tremendous progress in the design and study of nanomaterials geared towards biological and biomedical applications, most notable among these being the noble metal nanoparticles. In this review, we outline the surface-plasmon resonance-enhanced optical properties of colloidal gold nanoparticles directed towards recent biomedical applications with an emphasis on cancer diagnostics and therapeutics. Methods of molecular-specific diagnostics/detection of cancer including strongly enhanced surface plasmon resonance light-scattering, surface-enhanced emission of gold nanorods and surface-enhanced Raman scattering, are described. We also discuss the plasmonic photothermal therapy of cancer achieved by using the strongly enhanced surface-plasmon resonance absorption of gold nanospheres and nanorods.

Original languageEnglish (US)
Pages (from-to)681-693
Number of pages13
JournalNanomedicine
Volume2
Issue number5
DOIs
StatePublished - Oct 1 2007

Keywords

  • Cancer diagnostics
  • Gold nanoparticles
  • Gold nanorods
  • Mie scattering
  • Plasmonic photothermal therapy
  • Surface-enhanced Raman scattering
  • Two photon luminescence

ASJC Scopus subject areas

  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Development

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