Glycoconjugate synthesis using chemoselective ligation

Shuihong Cheng; Paeton L. Wantuch; Megan E. Kizer; Dustin R. Middleton; Ruitong Wang; Mikaela Dibello; Mingli Li; Xing Wang; Xuebing Li; Vasanthi Ramachandiran; Fikri Y. Avci; Fuming Zhang; Xing Zhang; Robert J. Linhardt

doi:10.1039/c9ob00270g

Glycoconjugate synthesis using chemoselective ligation

Shuihong Cheng, Paeton L. Wantuch, Megan E. Kizer, Dustin R. Middleton, Ruitong Wang, Mikaela Dibello, Mingli Li, Xing Wang, Xuebing Li, Vasanthi Ramachandiran, Fikri Y. Avci, Fuming Zhang, Xing Zhang, Robert J. Linhardt

Research output: Contribution to journal › Article › peer-review

Abstract

Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.

Original language	English (US)
Pages (from-to)	2646-2650
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	17
Issue number	10
DOIs	https://doi.org/10.1039/c9ob00270g
State	Published - 2019
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c9ob00270g

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title = "Glycoconjugate synthesis using chemoselective ligation",

abstract = "Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.",

author = "Shuihong Cheng and Wantuch, {Paeton L.} and Kizer, {Megan E.} and Middleton, {Dustin R.} and Ruitong Wang and Mikaela Dibello and Mingli Li and Xing Wang and Xuebing Li and Vasanthi Ramachandiran and Avci, {Fikri Y.} and Fuming Zhang and Xing Zhang and Linhardt, {Robert J.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

year = "2019",

doi = "10.1039/c9ob00270g",

language = "English (US)",

volume = "17",

pages = "2646--2650",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Glycoconjugate synthesis using chemoselective ligation

AU - Cheng, Shuihong

AU - Wantuch, Paeton L.

AU - Kizer, Megan E.

AU - Middleton, Dustin R.

AU - Wang, Ruitong

AU - Dibello, Mikaela

AU - Li, Mingli

AU - Wang, Xing

AU - Li, Xuebing

AU - Ramachandiran, Vasanthi

AU - Avci, Fikri Y.

AU - Zhang, Fuming

AU - Zhang, Xing

AU - Linhardt, Robert J.

PY - 2019

Y1 - 2019

N2 - Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.

AB - Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.

UR - http://www.scopus.com/inward/record.url?scp=85062620917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062620917&partnerID=8YFLogxK

U2 - 10.1039/c9ob00270g

DO - 10.1039/c9ob00270g

M3 - Article

C2 - 30778481

AN - SCOPUS:85062620917

SN - 1477-0520

VL - 17

SP - 2646

EP - 2650

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 10

ER -

Glycoconjugate synthesis using chemoselective ligation

Abstract

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