Glycoconjugate synthesis using chemoselective ligation

Shuihong Cheng, Paeton L. Wantuch, Megan E. Kizer, Dustin R. Middleton, Ruitong Wang, Mikaela Dibello, Mingli Li, Xing Wang, Xuebing Li, Vasanthi Ramachandiran, Fikri Y. Avci, Fuming Zhang, Xing Zhang, Robert J. Linhardt

Research output: Contribution to journalArticlepeer-review

Abstract

Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.

Original languageEnglish (US)
Pages (from-to)2646-2650
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume17
Issue number10
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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