Glutathione Utilization in Lactobacillus fermentum CECT 5716

Agustian Surya, Xiaoji Liu, Michael J. Miller

Research output: Contribution to journalArticlepeer-review


Glutathione, a tripeptide antioxidant, has recently been shown to be either utilized or synthesized by Gram-positive bacteria, such as lactic acid bacteria. Glutathione plays an important role in countering environmental stress, such as oxidative stress. In this study, cellular activity regarding glutathione in Lactobacillus fermentum CECT 5716 is characterized. We demonstrate that L. fermentum CECT 5716 has a better survival rate in the presence of glutathione under both oxidative and metal stress. As L. fermentum CECT 5716 does not possess the ability to synthesize glutathione under the conditions tested, it shows the ability to uptake both reduced and oxidized glutathione from the environment, regenerate reduced glutathione from oxidized glutathione, and perform secretion of glutathione to the environment.

Original languageEnglish (US)
Pages (from-to)12651-12656
Number of pages6
JournalJournal of Agricultural and Food Chemistry
Issue number48
StatePublished - Dec 5 2018


  • Lactobacillus fermentum
  • glutathione
  • lactic acid bacteria
  • metal stress
  • oxidative stress

ASJC Scopus subject areas

  • General Chemistry
  • General Agricultural and Biological Sciences


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