Glutathione-S-transferase μ and theta gene polymorphisms as new risk factors of atopic bronchial asthma

Fei Wang, Paul Herzmark, Orion D. Weiner, Supriya Srinivasan, Guy Servant, Henry R. Bourne

Research output: Contribution to journalArticle

Abstract

The genetic polymorphism of glutathione-S-transferase M1 (GSTM1) and glutathione-S-transferase T1 (GSTT1) genes and the cytochrome P4501A1 gene responsible for xenobiotic conjugating enzymes of the phase II and phase I detoxification system were studied by PCR-RFLP in the blood spots of 109 patients with atopic bronchial asthma and 90 healthy individuals. GSTM1 gene deletion (GSTM10/0) was detected in 47.8% of individuals in the control group and in 76.1% of asthmatic patients. Individuals without the GSTM1 gene were at approximately 3.5-fold higher risk of developing asthma. The proportion of GSTT10/0 genotypes was significantly higher in the group of asthmatics (67.0%) than in controls (23.3%). The proportion of individuals with a deficiency in both GSTM1 and GSTT1 gene activity was more than four times higher in asthmatic patients than in the control group (54.1% and 12.2%, respectively). The frequency of the Ile-Val polymorphism of the CYP1A1 gene was similar in controls and asthmatic patients. This study shows the association of atopic bronchial asthma with GSTM10/0, GSTT10/0 genotypes.

Original languageEnglish (US)
Pages (from-to)39-43
Number of pages5
JournalJournal of Molecular Medicine
Volume80
Issue number1
DOIs
StatePublished - Jan 1 2002

Keywords

  • Asthma
  • Cytochrome P4501A1
  • Gene polymorphism
  • Glutathione-S-transferase M1
  • Glutathione-S-transferase T1

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Genetics(clinical)

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