Glucose tolerance and insulin secretion in spontaneously hyperthyroid cats

M. Hoenig; M. E. Peterson; D. C. Ferguson

doi:10.1016/0034-5288(92)90136-P

Glucose tolerance and insulin secretion in spontaneously hyperthyroid cats

M. Hoenig, M. E. Peterson, D. C. Ferguson

Research output: Contribution to journal › Article › peer-review

Abstract

Glucose tolerance and insulin secretion after administration of a glucose load were determined in 11 clinically normal cats and 15 cats with spontaneous hyperthyroidism. In six hyperthyroid cats, a glucose tolerance test was repeated after treatment with radioactive iodine (¹³¹I). All cats had similar baseline glucose concentrations. However, the cats with hyperthyroidism had a significantly decreased glucose clearance, which was worse after treatment. Hyperthyroidism also caused a marked increase in basal and glucose-stimulated insulin secretion, which was not improved with treatment. It is concluded that hyperthyroidism in cats may lead to long-lasting alterations of glucose tolerance and insulin secretion which may not be reversed by treatment.

Original language	English (US)
Pages (from-to)	338-341
Number of pages	4
Journal	Research in Veterinary Science
Volume	53
Issue number	3
DOIs	https://doi.org/10.1016/0034-5288(92)90136-P
State	Published - Nov 1992
Externally published	Yes

ASJC Scopus subject areas

General Veterinary

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title = "Glucose tolerance and insulin secretion in spontaneously hyperthyroid cats",

abstract = "Glucose tolerance and insulin secretion after administration of a glucose load were determined in 11 clinically normal cats and 15 cats with spontaneous hyperthyroidism. In six hyperthyroid cats, a glucose tolerance test was repeated after treatment with radioactive iodine (131I). All cats had similar baseline glucose concentrations. However, the cats with hyperthyroidism had a significantly decreased glucose clearance, which was worse after treatment. Hyperthyroidism also caused a marked increase in basal and glucose-stimulated insulin secretion, which was not improved with treatment. It is concluded that hyperthyroidism in cats may lead to long-lasting alterations of glucose tolerance and insulin secretion which may not be reversed by treatment.",

author = "M. Hoenig and Peterson, {M. E.} and Ferguson, {D. C.}",

note = "Funding Information: Acknowledgements This work was supported in part by the Companion Animal Research Fund, College of Veterinary Medicine, University of Georgia. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

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AU - Peterson, M. E.

AU - Ferguson, D. C.

N1 - Funding Information: Acknowledgements This work was supported in part by the Companion Animal Research Fund, College of Veterinary Medicine, University of Georgia. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

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N2 - Glucose tolerance and insulin secretion after administration of a glucose load were determined in 11 clinically normal cats and 15 cats with spontaneous hyperthyroidism. In six hyperthyroid cats, a glucose tolerance test was repeated after treatment with radioactive iodine (131I). All cats had similar baseline glucose concentrations. However, the cats with hyperthyroidism had a significantly decreased glucose clearance, which was worse after treatment. Hyperthyroidism also caused a marked increase in basal and glucose-stimulated insulin secretion, which was not improved with treatment. It is concluded that hyperthyroidism in cats may lead to long-lasting alterations of glucose tolerance and insulin secretion which may not be reversed by treatment.

AB - Glucose tolerance and insulin secretion after administration of a glucose load were determined in 11 clinically normal cats and 15 cats with spontaneous hyperthyroidism. In six hyperthyroid cats, a glucose tolerance test was repeated after treatment with radioactive iodine (131I). All cats had similar baseline glucose concentrations. However, the cats with hyperthyroidism had a significantly decreased glucose clearance, which was worse after treatment. Hyperthyroidism also caused a marked increase in basal and glucose-stimulated insulin secretion, which was not improved with treatment. It is concluded that hyperthyroidism in cats may lead to long-lasting alterations of glucose tolerance and insulin secretion which may not be reversed by treatment.

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Glucose tolerance and insulin secretion in spontaneously hyperthyroid cats

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