Glucagon-like peptide 1 and appetite

Megan J. Dailey; Timothy H. Moran

doi:10.1016/j.tem.2012.11.008

Glucagon-like peptide 1 and appetite

Megan J. Dailey, Timothy H. Moran

Research output: Contribution to journal › Review article › peer-review

Abstract

Glucagon-like peptide 1 (GLP-1) and GLP-1 analogs have received much recent attention due to the success of GLP-1 mimetics in treating type II diabetes mellitus (T2DM), but these compounds may also have the potential to treat obesity. The satiety effect of GLP-1 may involve both within-meal enteroenteric reflexes, and across-meal central signaling mechanisms, that mediate changes in appetite and promote satiety. Here, we review data supporting the role of both peripheral and central GLP-1 signaling in the control of gastrointestinal motility and food intake. Understanding the mechanisms underlying the appetite-suppressive effects of GLP-1 may help in developing targeted treatments for obesity.

Original language	English (US)
Pages (from-to)	85-91
Number of pages	7
Journal	Trends in Endocrinology and Metabolism
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/j.tem.2012.11.008
State	Published - Feb 2013
Externally published	Yes

Keywords

Appetite
Food intake
GLP-1
Gastrointestinal motility

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

Online availability

10.1016/j.tem.2012.11.008

Library availability

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AB - Glucagon-like peptide 1 (GLP-1) and GLP-1 analogs have received much recent attention due to the success of GLP-1 mimetics in treating type II diabetes mellitus (T2DM), but these compounds may also have the potential to treat obesity. The satiety effect of GLP-1 may involve both within-meal enteroenteric reflexes, and across-meal central signaling mechanisms, that mediate changes in appetite and promote satiety. Here, we review data supporting the role of both peripheral and central GLP-1 signaling in the control of gastrointestinal motility and food intake. Understanding the mechanisms underlying the appetite-suppressive effects of GLP-1 may help in developing targeted treatments for obesity.

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Glucagon-like peptide 1 and appetite

Abstract

Keywords

ASJC Scopus subject areas

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