TY - JOUR
T1 - Geometrical Effect in 2D Nanopores
AU - Liu, Ke
AU - Lihter, Martina
AU - Sarathy, Aditya
AU - Caneva, Sabina
AU - Qiu, Hu
AU - Deiana, Davide
AU - Tileli, Vasiliki
AU - Alexander, Duncan T.L.
AU - Hofmann, Stephan
AU - Dumcenco, Dumitru
AU - Kis, Andras
AU - Leburton, Jean Pierre
AU - Radenovic, Aleksandra
N1 - Funding Information:
This work was financially supported by the European Research Council (grant 259398, PorABEL), by a Swiss National Science Foundation (SNSF) Consolidator grant (BIONIC BSCGI0-157802), by SNSF Sinergia grant 147607. We thank the Centre Interdisciplinaire de Microscopie Electronique (CIME) at the Ecole Polytechnique federale de Lausanne (EPFL) for access to electron microscopes. Device fabrication was partially carried out at the EPFL Center for Micro/Nanotechnology (CMi). Special thanks to Ms. Anna Carlsson from FEI for the help in HRTEM imaging. The authors would like to thank Ulrich Keyser and Michael Walker for their helpful and constructive comments that greatly contributed to improving the quality of the paper. The work performed in Cambridge was supported by the EPSRC Cambridge NanoDTC, EP/L015978/1. The work performed in UIUC was supported by grants from Oxford Nanopore Technology and the Seeding Novel Interdisciplinary Research Program of the Beckman Institute. The UIUC authors gratefully acknowledge also supercomputer time provided through the Extreme Science and Engineering Discovery Environment (XSEDE) grant MCA93S028 and by the University of Illinois at Urbana-Champaign on the TAUB cluster. H.Q. acknowledges the computational support of the NSF China (11402113) and Jiangsu NSF (BK20140807).
Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/7/12
Y1 - 2017/7/12
N2 - A long-standing problem in the application of solid-state nanopores is the lack of the precise control over the geometry of artificially formed pores compared to the well-defined geometry in their biological counterpart, that is, protein nanopores. To date, experimentally investigated solid-state nanopores have been shown to adopt an approximately circular shape. In this Letter, we investigate the geometrical effect of the nanopore shape on ionic blockage induced by DNA translocation using triangular h-BN nanopores and approximately circular molybdenum disulfide (MoS2) nanopores. We observe a striking geometry-dependent ion scattering effect, which is further corroborated by a modified ionic blockage model. The well-acknowledged ionic blockage model is derived from uniform ion permeability through the 2D nanopore plane and hemisphere like access region in the nanopore vicinity. On the basis of our experimental results, we propose a modified ionic blockage model, which is highly related to the ionic profile caused by geometrical variations. Our findings shed light on the rational design of 2D nanopores and should be applicable to arbitrary nanopore shapes.
AB - A long-standing problem in the application of solid-state nanopores is the lack of the precise control over the geometry of artificially formed pores compared to the well-defined geometry in their biological counterpart, that is, protein nanopores. To date, experimentally investigated solid-state nanopores have been shown to adopt an approximately circular shape. In this Letter, we investigate the geometrical effect of the nanopore shape on ionic blockage induced by DNA translocation using triangular h-BN nanopores and approximately circular molybdenum disulfide (MoS2) nanopores. We observe a striking geometry-dependent ion scattering effect, which is further corroborated by a modified ionic blockage model. The well-acknowledged ionic blockage model is derived from uniform ion permeability through the 2D nanopore plane and hemisphere like access region in the nanopore vicinity. On the basis of our experimental results, we propose a modified ionic blockage model, which is highly related to the ionic profile caused by geometrical variations. Our findings shed light on the rational design of 2D nanopores and should be applicable to arbitrary nanopore shapes.
KW - 2D materials
KW - Solid-state nanopores
KW - hexagonal boron nitride (h-BN)
KW - high-resolution transmission electron microscopy (HRTEM)
KW - ion transport
KW - molybdenum disulfide (MoS)
UR - http://www.scopus.com/inward/record.url?scp=85027036685&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027036685&partnerID=8YFLogxK
U2 - 10.1021/acs.nanolett.7b01091
DO - 10.1021/acs.nanolett.7b01091
M3 - Article
C2 - 28592108
AN - SCOPUS:85027036685
SN - 1530-6984
VL - 17
SP - 4223
EP - 4230
JO - Nano letters
JF - Nano letters
IS - 7
ER -