@article{8c5f26a7bea94925bd71ed5dac5263c2,
title = "Geobiology reveals how human kidney stones dissolve in vivo",
abstract = "More than 10% of the global human population is now afflicted with kidney stones, which are commonly associated with other significant health problems including diabetes, hypertension and obesity. Nearly 70% of these stones are primarily composed of calcium oxalate, a mineral previously assumed to be effectively insoluble within the kidney. This has limited currently available treatment options to painful passage and/or invasive surgical procedures. We analyze kidney stone thin sections with a combination of optical techniques, which include bright field, polarization, confocal and super-resolution nanometer-scale auto-fluorescence microscopy. Here we demonstrate using interdisciplinary geology and biology (geobiology) approaches that calcium oxalate stones undergo multiple events of dissolution as they crystallize and grow within the kidney. These observations open a fundamentally new paradigm for clinical approaches that include in vivo stone dissolution and identify high-frequency layering of organic matter and minerals as a template for biomineralization in natural and engineered settings.",
author = "Mayandi Sivaguru and Saw, {Jessica J.} and Williams, {James C.} and Lieske, {John C.} and Krambeck, {Amy E.} and Romero, {Michael F.} and Nicholas Chia and Schwaderer, {Andrew L.} and Alcalde, {Reinaldo E.} and Bruce, {William J.} and Wildman, {Derek E.} and Fried, {Glenn A.} and Werth, {Charles J.} and Reeder, {Richard J.} and Yau, {Peter M.} and Sanford, {Robert A.} and Fouke, {Bruce W.}",
note = "Funding Information: Kidney stone samples were collected following Mayo Clinic Institutional Review Board approval (IRB 09-002083) and written patient consent. This research was supported by the Mayo Clinic and University of Illinois Strategic Alliance for Technology-Based Healthcare, the Mayo Clinic O{\textquoteright}Brien Urology Research Center (No. DK100227), the Mayo Special Undergraduate Research Fellowship (SURF), and the National Aeronautics and Space Administration (NASA) Astrobiology Institute (Cooperative Agreement No. NNA13AA91A) issued through the Science Mission Directorate. K. Lee conducted EDXS analyses at the Illinois Beckman Institute. We thank G. Robinson, N. Goldenfeld, B. White, Y. Dong, A. Merkel, J. Webber, M. Cregger, M. Baughman, L. Shechtman, E. Wilson, M. Casagrande, B. Sivaguru, V. Sivaguru, L. Nazal, T. Rauschfuss, D. Bish and B. Michelson for their contributions in editing the final manuscript and/or sample preparation. Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41598-018-31890-9",
language = "English (US)",
volume = "8",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}