Genotype-agnostic rescue of cystic fibrosis with small molecule bicarbonate channels

Martin D. Burke; Katrina A. (Diaz) Muraglia; Rajeev S. Chorghade; Michael Welsh

Genotype-agnostic rescue of cystic fibrosis with small molecule bicarbonate channels

Martin D. Burke (Inventor), Katrina A. (Diaz) Muraglia (Inventor), Rajeev S. Chorghade (Inventor), Michael Welsh (Inventor)

Research output: Patent

Abstract

Disclosed are methods of treating cystic fibrosis using AmB and a sterol or compositions comprising AmB and a sterol. Also disclosed are methods of increasing the pH of airway surface liquid in a patient having cystic fibrosis using AmB and a sterol; and methods of decreasing the viscosity of airway surface liquid in a patient having cystic fibrosis using AmB and a sterol.

Original language	English (US)
U.S. patent number	12090164
Filing date	10/11/18
State	Published - Sep 17 2024

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title = "Genotype-agnostic rescue of cystic fibrosis with small molecule bicarbonate channels",

abstract = "Disclosed are methods of treating cystic fibrosis using AmB and a sterol or compositions comprising AmB and a sterol. Also disclosed are methods of increasing the pH of airway surface liquid in a patient having cystic fibrosis using AmB and a sterol; and methods of decreasing the viscosity of airway surface liquid in a patient having cystic fibrosis using AmB and a sterol.",

author = "Burke, {Martin D.} and {(Diaz) Muraglia}, {Katrina A.} and Chorghade, {Rajeev S.} and Michael Welsh",

note = "GOVERNMENT SUPPORT This invention was made with government support under grant number GM118185, awarded by The National Institutes of Health. The government has certain rights in the invention.; 12090164",

year = "2024",

month = sep,

day = "17",

language = "English (US)",

type = "Patent",

}

TY - PAT

T1 - Genotype-agnostic rescue of cystic fibrosis with small molecule bicarbonate channels

AU - Burke, Martin D.

AU - (Diaz) Muraglia, Katrina A.

AU - Chorghade, Rajeev S.

AU - Welsh, Michael

N1 - GOVERNMENT SUPPORT This invention was made with government support under grant number GM118185, awarded by The National Institutes of Health. The government has certain rights in the invention.

PY - 2024/9/17

Y1 - 2024/9/17

N2 - Disclosed are methods of treating cystic fibrosis using AmB and a sterol or compositions comprising AmB and a sterol. Also disclosed are methods of increasing the pH of airway surface liquid in a patient having cystic fibrosis using AmB and a sterol; and methods of decreasing the viscosity of airway surface liquid in a patient having cystic fibrosis using AmB and a sterol.

AB - Disclosed are methods of treating cystic fibrosis using AmB and a sterol or compositions comprising AmB and a sterol. Also disclosed are methods of increasing the pH of airway surface liquid in a patient having cystic fibrosis using AmB and a sterol; and methods of decreasing the viscosity of airway surface liquid in a patient having cystic fibrosis using AmB and a sterol.

M3 - Patent

M1 - 12090164

Y2 - 2018/10/11

ER -

Genotype-agnostic rescue of cystic fibrosis with small molecule bicarbonate channels

Abstract

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