Genomics-enabled discovery of phosphonate natural products and their biosynthetic pathways

Kou San Ju, James R. Doroghazi, William W. Metcalf

Research output: Contribution to journalReview articlepeer-review


Phosphonate natural products have proven to be a rich source of useful pharmaceutical, agricultural, and biotechnology products, whereas study of their biosynthetic pathways has revealed numerous intriguing enzymes that catalyze unprecedented biochemistry. Here we review the history of phosphonate natural product discovery, highlighting technological advances that have played a key role in the recent advances in their discovery. Central to these developments has been the application of genomics, which allowed discovery and development of a global phosphonate metabolic framework to guide research efforts. This framework suggests that the future of phosphonate natural products remains bright, with many new compounds and pathways yet to be discovered.

Original languageEnglish (US)
Pages (from-to)345-356
Number of pages12
JournalJournal of Industrial Microbiology and Biotechnology
Issue number2
StatePublished - Feb 2014


  • Antibiotic
  • Genome mining
  • Natural product
  • Phosphonate
  • Streptomyces

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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