Genomic variants of TLR1 - It takes (TLR-)two to tango

Ralf R. Schumann, Richard I. Tapping

    Research output: Contribution to journalComment/debatepeer-review

    Abstract

    Toll-like receptors (TLR) are innate immune sensors of microbial cell wall products that initiate early host responses. The TLR2 receptor complex has been shown to contain heterodimers of TLR2 with either TIR1 or TLR6 enabling the host to detect different microbial molecules, such as lipopeptides of different chemical composition. In this issue of the European Journal of Immunology, an important role in the sensing of microbial products for 1602S, a single nucleotide polymorphism (SNP) in human TLR1 has been identified. This result, in combination with another recently published report on this polymorphism elucidating a functional role in cell trafficking (surface expression of the receptor complex in individuals carrying the SNP was altered), provide genetic evidence affirming the important function of TLR1 as an essential co-receptor for TLR2.

    Original languageEnglish (US)
    Pages (from-to)2059-2062
    Number of pages4
    JournalEuropean Journal of Immunology
    Volume37
    Issue number8
    DOIs
    StatePublished - Aug 2007

    Keywords

    • Disease susceptibility
    • Genotyping
    • Single nucleotide polymorphisms
    • TLR
    • TLR2/1

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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