TY - JOUR
T1 - Genomic responses to selection for tame/aggressive behaviors in the silver fox (Vulpes vulpes)
AU - Wang, Xu
AU - Pipes, Lenore
AU - Trut, Lyudmila N.
AU - Herbeck, Yury
AU - Vladimirova, Anastasiya V.
AU - Gulevich, Rimma G.
AU - Kharlamova, Anastasiya V.
AU - Johnson, Jennifer L.
AU - Acland, Gregory M.
AU - Kukekova, Anna V.
AU - Clark, Andrew G.
N1 - Funding Information:
ACKNOWLEDGMENTS. We thank Hopi Hoekstra and Robert Wayne for comments on the manuscript, Marcos Simoes-Costa for discussions, and Amanda Manfredo and Li (Grace) Chi for assistance with the experiments. We are grateful to Irina V. Pivovarova, Tatyana I. Semenova, and all the animal keepers at the ICG experimental farm for research assistance. The project was supported by National Institutes of Health (Grant GM120782), US Department of Agriculture (Federal Hatch Project 538922), The Russian Federal Complex Program Grant 84-74, Russian Science Foundation (Grant 16-14-10216; animal behavior analysis and sample collection), the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences (Grant 0324-2018-0016; animal maintenance), and a Meinig Family Investigator Award (to A.G.C.).
PY - 2018/10/9
Y1 - 2018/10/9
N2 - Animal domestication efforts have led to a shared spectrum of striking behavioral and morphological changes. To recapitulate this process, silver foxes have been selectively bred for tame and aggressive behaviors for more than 50 generations at the Institute for Cytology and Genetics in Novosibirsk, Russia. To understand the genetic basis and molecular mechanisms underlying the phenotypic changes, we profiled gene expression levels and coding SNP allele frequencies in two brain tissue specimens from 12 aggressive foxes and 12 tame foxes. Expression analysis revealed 146 genes in the prefrontal cortex and 33 genes in the basal forebrain that were differentially expressed, with a 5% false discovery rate (FDR). These candidates include genes in key pathways known to be critical to neurologic processing, including the serotonin and glutamate receptor pathways. In addition, 295 of the 31,000 exonic SNPs show significant allele frequency differences between the tame and aggressive populations (1% FDR), including genes with a role in neural crest cell fate determination.
AB - Animal domestication efforts have led to a shared spectrum of striking behavioral and morphological changes. To recapitulate this process, silver foxes have been selectively bred for tame and aggressive behaviors for more than 50 generations at the Institute for Cytology and Genetics in Novosibirsk, Russia. To understand the genetic basis and molecular mechanisms underlying the phenotypic changes, we profiled gene expression levels and coding SNP allele frequencies in two brain tissue specimens from 12 aggressive foxes and 12 tame foxes. Expression analysis revealed 146 genes in the prefrontal cortex and 33 genes in the basal forebrain that were differentially expressed, with a 5% false discovery rate (FDR). These candidates include genes in key pathways known to be critical to neurologic processing, including the serotonin and glutamate receptor pathways. In addition, 295 of the 31,000 exonic SNPs show significant allele frequency differences between the tame and aggressive populations (1% FDR), including genes with a role in neural crest cell fate determination.
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U2 - 10.1073/pnas.1800889115
DO - 10.1073/pnas.1800889115
M3 - Article
C2 - 30228118
AN - SCOPUS:85054774618
VL - 115
SP - 10398
EP - 10403
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 41
ER -