Genome-Wide analysis and prediction of resistance to goss’s wilt in maize

Julian S. Cooper, Brian R. Rice, Esperanza M. Shenstone, Alexander E. Lipka, Tiffany M. Jamann

Research output: Contribution to journalArticle

Abstract

Goss’s bacterial wilt and leaf blight is one of the most important foliar diseases of maize (Zea mays L.). To date, neither large-effect resistance genes, nor practical chemical controls exist to manage the disease. Thus, the importance of discovering durable host resistance necessitates additional genetic mapping for this disease. Unfortunately, because of the biology of the pathogen and the highly significant genotypeby- environment interaction effect observed with Goss’s wilt, consistent phenotyping across multiple years poses a hurdle for genetic studies and conventional breeding methods. The objective of this study was to perform a genome-wide association study (GWAS) to identify regions of the genome associated with Goss’s wilt resistance as well as to use genomic prediction models to evaluate the utility of genomic selection (GS) in predicting Goss’s wilt phenotypes in a panel of diverse maize lines. Using genome-wide association mapping, we were unable to identify any variants significantly associated with Goss’s wilt. However, using genomic prediction we were able to train a model with an accuracy of 0.69. Taken together, this suggests that resistance to Goss’s wilt is highly polygenic. In addition, when evaluating the accuracy of our prediction model under reduced marker density, it was shown that only 10,000 single nucleotide polymorphisms (SNPs), or ~20% of our total marker set, was necessary to achieve prediction accuracies similar to the full marker set. This is the first report of genomic prediction for a bacterial disease of maize, and these results highlight the potential of GS for disease resistance in maize.

Original languageEnglish (US)
Article number180045
JournalPlant Genome
Volume12
Issue number2
DOIs
StatePublished - Jun 2019

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Zea mays
Genome
genome
prediction
corn
genomics
marker-assisted selection
chromosome mapping
phenotype
bacterial wilt
Inborn Genetic Diseases
Disease Resistance
leaf blight
breeding methods
Genome-Wide Association Study
foliar diseases
chemical control
single nucleotide polymorphism
Breeding
Single Nucleotide Polymorphism

ASJC Scopus subject areas

  • Genetics
  • Agronomy and Crop Science
  • Plant Science

Cite this

Genome-Wide analysis and prediction of resistance to goss’s wilt in maize. / Cooper, Julian S.; Rice, Brian R.; Shenstone, Esperanza M.; Lipka, Alexander E.; Jamann, Tiffany M.

In: Plant Genome, Vol. 12, No. 2, 180045, 06.2019.

Research output: Contribution to journalArticle

Cooper, Julian S. ; Rice, Brian R. ; Shenstone, Esperanza M. ; Lipka, Alexander E. ; Jamann, Tiffany M. / Genome-Wide analysis and prediction of resistance to goss’s wilt in maize. In: Plant Genome. 2019 ; Vol. 12, No. 2.
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