@article{991e774cdcc04e5499d0b86c2dde5302,
title = "Genome organization around nuclear speckles",
abstract = "Higher eukaryotic cell nuclei are highly compartmentalized into bodies and structural assemblies of specialized functions. Nuclear speckles/IGCs are one of the most prominent nuclear bodies, yet their functional significance remains largely unknown. Recent advances in sequence-based mapping of nuclear genome organization now provide genome-wide analysis of chromosome organization relative to nuclear speckles. Here we review older microscopy-based studies on a small number of genes with the new genomic mapping data suggesting a significant fraction of the genome is almost deterministically positioned near nuclear speckles. Both microscopy and genomic-based approaches support the concept of the nuclear speckle periphery as a major active chromosomal compartment which may play an important role in fine-tuning gene regulation.",
author = "Yu Chen and Belmont, {Andrew S.}",
note = "Funding Information: We thank Michael Hendzel, University of Alberta, for his contribution of Figure 1b, and Yaron Shav-Tal, Bar-Ilan University, for his ideas about nuclear speckles buffering nucleoplasmic levels of RNA processing factors and sharing his paper before publication. We apologize to colleagues whose work was not mentioned due to space limitations. Funding: ASB acknowledges support from National Institutes of Health R01 grant GM58460 and from its Common Fund 4D Nucleome Program (U54 DK107965). Funding Information: We thank Michael Hendzel, University of Alberta, for his contribution of Figure 1 b, and Yaron Shav-Tal, Bar-Ilan University, for his ideas about nuclear speckles buffering nucleoplasmic levels of RNA processing factors and sharing his paper before publication. We apologize to colleagues whose work was not mentioned due to space limitations. Funding: ASB acknowledges support from National Institutes of Health R01 grant GM58460 and from its Common Fund 4D Nucleome Program ( U54 DK107965 ). Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
month = apr,
doi = "10.1016/j.gde.2019.06.008",
language = "English (US)",
volume = "55",
pages = "91--99",
journal = "Current Opinion in Genetics and Development",
issn = "0959-437X",
publisher = "Elsevier Limited",
}