Genome mining for ribosomally synthesized natural products

Juan E. Velásquez, Wilfred A. Van der Donk

Research output: Contribution to journalReview article

Abstract

In recent years, the number of known peptide natural products that are synthesized via the ribosomal pathway has rapidly grown. Taking advantage of sequence homology among genes encoding precursor peptides or biosynthetic proteins, in silico mining of genomes combined with molecular biology approaches has guided the discovery of a large number of new ribosomal natural products, including lantipeptides, cyanobactins, linear thiazole/oxazole-containing peptides, microviridins, lasso peptides, amatoxins, cyclotides, and conopeptides. In this review, we describe the strategies used for the identification of these ribosomally synthesized and posttranslationally modified peptides (RiPPs) and the structures of newly identified compounds. The increasing number of chemical entities and their remarkable structural and functional diversity may lead to novel pharmaceutical applications.

Original languageEnglish (US)
Pages (from-to)11-21
Number of pages11
JournalCurrent Opinion in Chemical Biology
Volume15
Issue number1
DOIs
StatePublished - Feb 1 2011

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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