Genistein, an epigenome modifier during cancer prevention

Yukun Zhang, Hong Chen

Research output: Contribution to journalArticle

Abstract

Dietary compounds have been observed to have a great potential to regulate the epigenome, which is disrupted and reprogrammed during carcinogenesis. Because of their close association with cancer development, DNA methylation patterns have been used as a crucial marker for the study of cancer-related epigenetics. There is immense evidence indicating that dietary components play a critical role in cancer development. Genistein, one of the soy-derived bioactive isoflavones, affects tumorigenesis through epigenetic regulations. By modulating chromatin configuration and DNA methylation, genistein activates tumor suppressor genes and affects cancer cell survival. Here, we summarize and discuss both in vitro and in vivo studies in the field that investigate the effect of genistein on histone modifications and DNA methylation. The promising role of genistein in cancer prevention and therapeutic applications will be discussed from an epigenetic point of view.

Original languageEnglish (US)
Pages (from-to)888-891
Number of pages4
JournalEpigenetics
Volume6
Issue number7
DOIs
StatePublished - Jul 2011

Fingerprint

Genistein
DNA Methylation
Epigenomics
Neoplasms
Carcinogenesis
Histone Code
Isoflavones
Tumor Suppressor Genes
Chromatin
Cell Survival

Keywords

  • Cancer epigenetics
  • DNA methylation
  • Early life exposure
  • Histone code
  • Maternal genistein
  • Soy isoflavone

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research

Cite this

Genistein, an epigenome modifier during cancer prevention. / Zhang, Yukun; Chen, Hong.

In: Epigenetics, Vol. 6, No. 7, 07.2011, p. 888-891.

Research output: Contribution to journalArticle

Zhang, Yukun ; Chen, Hong. / Genistein, an epigenome modifier during cancer prevention. In: Epigenetics. 2011 ; Vol. 6, No. 7. pp. 888-891.
@article{c557ca329f4b491ea23c02a1b23b50de,
title = "Genistein, an epigenome modifier during cancer prevention",
abstract = "Dietary compounds have been observed to have a great potential to regulate the epigenome, which is disrupted and reprogrammed during carcinogenesis. Because of their close association with cancer development, DNA methylation patterns have been used as a crucial marker for the study of cancer-related epigenetics. There is immense evidence indicating that dietary components play a critical role in cancer development. Genistein, one of the soy-derived bioactive isoflavones, affects tumorigenesis through epigenetic regulations. By modulating chromatin configuration and DNA methylation, genistein activates tumor suppressor genes and affects cancer cell survival. Here, we summarize and discuss both in vitro and in vivo studies in the field that investigate the effect of genistein on histone modifications and DNA methylation. The promising role of genistein in cancer prevention and therapeutic applications will be discussed from an epigenetic point of view.",
keywords = "Cancer epigenetics, DNA methylation, Early life exposure, Histone code, Maternal genistein, Soy isoflavone",
author = "Yukun Zhang and Hong Chen",
year = "2011",
month = "7",
doi = "10.4161/epi.6.7.16315",
language = "English (US)",
volume = "6",
pages = "888--891",
journal = "Epigenetics",
issn = "1559-2294",
publisher = "Landes Bioscience",
number = "7",

}

TY - JOUR

T1 - Genistein, an epigenome modifier during cancer prevention

AU - Zhang, Yukun

AU - Chen, Hong

PY - 2011/7

Y1 - 2011/7

N2 - Dietary compounds have been observed to have a great potential to regulate the epigenome, which is disrupted and reprogrammed during carcinogenesis. Because of their close association with cancer development, DNA methylation patterns have been used as a crucial marker for the study of cancer-related epigenetics. There is immense evidence indicating that dietary components play a critical role in cancer development. Genistein, one of the soy-derived bioactive isoflavones, affects tumorigenesis through epigenetic regulations. By modulating chromatin configuration and DNA methylation, genistein activates tumor suppressor genes and affects cancer cell survival. Here, we summarize and discuss both in vitro and in vivo studies in the field that investigate the effect of genistein on histone modifications and DNA methylation. The promising role of genistein in cancer prevention and therapeutic applications will be discussed from an epigenetic point of view.

AB - Dietary compounds have been observed to have a great potential to regulate the epigenome, which is disrupted and reprogrammed during carcinogenesis. Because of their close association with cancer development, DNA methylation patterns have been used as a crucial marker for the study of cancer-related epigenetics. There is immense evidence indicating that dietary components play a critical role in cancer development. Genistein, one of the soy-derived bioactive isoflavones, affects tumorigenesis through epigenetic regulations. By modulating chromatin configuration and DNA methylation, genistein activates tumor suppressor genes and affects cancer cell survival. Here, we summarize and discuss both in vitro and in vivo studies in the field that investigate the effect of genistein on histone modifications and DNA methylation. The promising role of genistein in cancer prevention and therapeutic applications will be discussed from an epigenetic point of view.

KW - Cancer epigenetics

KW - DNA methylation

KW - Early life exposure

KW - Histone code

KW - Maternal genistein

KW - Soy isoflavone

UR - http://www.scopus.com/inward/record.url?scp=79960128700&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960128700&partnerID=8YFLogxK

U2 - 10.4161/epi.6.7.16315

DO - 10.4161/epi.6.7.16315

M3 - Article

C2 - 21610327

AN - SCOPUS:79960128700

VL - 6

SP - 888

EP - 891

JO - Epigenetics

JF - Epigenetics

SN - 1559-2294

IS - 7

ER -