TY - JOUR
T1 - Genetics of behavior in the silver fox
AU - Kukekova, Anna V.
AU - Temnykh, Svetlana V.
AU - Johnson, Jennifer L.
AU - Trut, Lyudmila N.
AU - Acland, Gregory M.
N1 - Funding Information:
We are grateful to Irina V. Pivovarova, Anastasiya V. Vladimirova, Tatyana I. Semenova, and all the animal keepers at the ICG experimental farm for research assistance. We thank Dr. Aaron Wong and Dr. Mark Neff for providing information on amplification and polymorphism of a large set of newly developed canine SSR markers using a panel of fox DNA samples. We thank Dr. K. Gordon Lark and Kevin Chase, Anastasiya V. Kharlamova, Irina N. Oskina, and Rimma G. Gulevich for insightful discussions. GMA and AVK gratefully acknowledge NEI/NIH grants RO1MH077811, RO1EY006855, and R24GM082910; the support of a Roche Sequencing Grant; a CRIS/USDA Grant; and a CVG Seed Grant Award from the Cornell University Center for Vertebrate Genomics.
PY - 2012/2
Y1 - 2012/2
N2 - The silver fox provides a rich resource for investigating the genetics of behavior, with strains developed by intensely selective breeding that display markedly different behavioral phenotypes. Until recently, however, the tools for conducting molecular genetic investigations in this species were very limited. In this review, the history of development of this resource and the tools to exploit it are described. Although the focus is on the genetics of domestication in the silver fox, there is a broader context. In particular, one expectation of the silver fox research is that it will be synergistic with studies in other species, including humans, to yield a more comprehensive understanding of the molecular mechanisms and evolution of a wider range of social cognitive behaviors.
AB - The silver fox provides a rich resource for investigating the genetics of behavior, with strains developed by intensely selective breeding that display markedly different behavioral phenotypes. Until recently, however, the tools for conducting molecular genetic investigations in this species were very limited. In this review, the history of development of this resource and the tools to exploit it are described. Although the focus is on the genetics of domestication in the silver fox, there is a broader context. In particular, one expectation of the silver fox research is that it will be synergistic with studies in other species, including humans, to yield a more comprehensive understanding of the molecular mechanisms and evolution of a wider range of social cognitive behaviors.
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U2 - 10.1007/s00335-011-9373-z
DO - 10.1007/s00335-011-9373-z
M3 - Article
C2 - 22108806
AN - SCOPUS:84857366029
SN - 0938-8990
VL - 23
SP - 164
EP - 177
JO - Mammalian Genome
JF - Mammalian Genome
IS - 1-2
ER -