Genetic variation of porcine circovirus type 2 (PCV2) and its relevance to vaccination, pathogenesis and diagnosis

Benjamin R. Trible, Raymond R.R. Rowland

Research output: Contribution to journalReview articlepeer-review

Abstract

Porcine circovirus-associated disease (PCVAD) encompasses a group of complex, multi-factorial syndromes, which are dependent on infection with porcine circovirus type 2 (PCV2). Current strains of PCV2 circulating in the field are classified into two groups, termed PCV2a and PCV2b. Outbreaks of severe PCVAD in North America and other countries are often linked to a shift from PCV2a to PCV2b as the predominant genotype. Therefore, genotype-specific differences in pathogenesis and antigenicity have been suggested. Overall, evidence suggests that virulence is a function of the specific PCV2 isolate, regardless of genotype. In addition, only minor antigenic differences have been reported. In terms of immunopathogenesis, a conserved decoy epitope, located in the C-terminal region of the capsid protein, provides an explanation for the inability to identify pathogenic differences between genotypes. Finally, genetic variation in PCV2 and the resulting consequences with respect to vaccination and diagnostics are discussed.

Original languageEnglish (US)
Pages (from-to)68-77
Number of pages10
JournalVirus Research
Volume164
Issue number1-2
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

Keywords

  • PCV2
  • PCV2 genetic variation
  • PCV2 pathogenesis

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Cancer Research

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