Genetic Mouse Models for Female Reproductive Toxicology Studies

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The incidence of reproductive problems such as infertility and cancers in women has increased at an alarming rate, particularly in developed countries. One potential cause of the rising incidence of reproductive problems is exposure to by-products of industrialization such as man-made chemicals and additives. These man-made chemicals could mimic or interfere with reproductive hormones and their functions, therefore leading to reproductive disorders. In addition, certain populations could be more susceptible to particular types of man-made chemicals due to genetic polymorphisms. The advancement of transgenic technology in mice over the past decade has brought the field of reproductive toxicology to a critical crossroad. These genetic models create unique opportunities for reproductive toxicologists to explore questions that could never before be imagined. To take full advantage of the power of these genetic models, a basic understanding of both female reproduction and the strengths and limitations of the genetic models is necessary. It is hoped that this article will trigger interest in and promote better use of transgenic mouse models in female reproductive toxicology.

Original languageEnglish (US)
Title of host publicationReproductive and Endocrine Toxicology
PublisherElsevier Inc.
Pages470-494
Number of pages25
Volume4-15
ISBN (Electronic)9780081006122
ISBN (Print)9780081006016
DOIs
StatePublished - Jan 1 2018

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Keywords

  • Androgen receptors
  • Animal models
  • Aryl hydrocarbon receptors
  • Cyclooxygenase
  • Endocrine disruptors
  • Estrogen receptors
  • Female development
  • Female reproduction
  • Follicle-stimulating hormone receptors
  • Knockout
  • Luteinizing hormone receptors
  • Ovary
  • Peroxisome proliferator-activated receptors
  • Progesterone receptors
  • Prolactin receptors
  • Prostaglandin receptors
  • Reproductive tract
  • Steroidogenesis
  • Transforming growth factor-beta superfamily receptors
  • Transgenic mice

ASJC Scopus subject areas

  • Medicine(all)

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