Genetic mapping of five human chromosome 4 orthologues to bovine chromosomes 6 and 17

S. R. Fisher; J. E. Beever; H. A. Lewin

doi:10.1111/j.1365-2052.1997.00131.x

Genetic mapping of five human chromosome 4 orthologues to bovine chromosomes 6 and 17

S. R. Fisher, J. E. Beever, H. A. Lewin

Animal Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Five loci that map to human chromosome 4 (HSA4) were selected to expand the bovine comparative linkage map. Loci included b-casein (CSN2), basic fibroblast growth factor (FGF2), immunoglobulin J chain (IGJ), interleukin 2 (IL2) and microsomal triglyceride transfer protein (MTTP). Polymorphisms for each locus were identified by either polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) or single-strand conformational polymorphism (SSCP) analysis. The bovine genes for CSN2, IGJ and MTTP were mapped by linkage analysis to chromosome 6; FGF2 and IL2 mapped to chromosome 17. These data refine a position of chromosomal evolution to a small region between FGF2 and the previously mapped complement I factor (IF).

Original language	English (US)
Pages (from-to)	253-257
Number of pages	5
Journal	Animal genetics
Volume	28
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2052.1997.00131.x
State	Published - Aug 1997

Keywords

Bovine
Comparative mapping
Genetic linkage

ASJC Scopus subject areas

Animal Science and Zoology
Genetics

Online availability

10.1111/j.1365-2052.1997.00131.x

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title = "Genetic mapping of five human chromosome 4 orthologues to bovine chromosomes 6 and 17",

abstract = "Five loci that map to human chromosome 4 (HSA4) were selected to expand the bovine comparative linkage map. Loci included b-casein (CSN2), basic fibroblast growth factor (FGF2), immunoglobulin J chain (IGJ), interleukin 2 (IL2) and microsomal triglyceride transfer protein (MTTP). Polymorphisms for each locus were identified by either polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) or single-strand conformational polymorphism (SSCP) analysis. The bovine genes for CSN2, IGJ and MTTP were mapped by linkage analysis to chromosome 6; FGF2 and IL2 mapped to chromosome 17. These data refine a position of chromosomal evolution to a small region between FGF2 and the previously mapped complement I factor (IF).",

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year = "1997",

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journal = "Animal genetics",

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AU - Fisher, S. R.

AU - Beever, J. E.

AU - Lewin, H. A.

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AB - Five loci that map to human chromosome 4 (HSA4) were selected to expand the bovine comparative linkage map. Loci included b-casein (CSN2), basic fibroblast growth factor (FGF2), immunoglobulin J chain (IGJ), interleukin 2 (IL2) and microsomal triglyceride transfer protein (MTTP). Polymorphisms for each locus were identified by either polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) or single-strand conformational polymorphism (SSCP) analysis. The bovine genes for CSN2, IGJ and MTTP were mapped by linkage analysis to chromosome 6; FGF2 and IL2 mapped to chromosome 17. These data refine a position of chromosomal evolution to a small region between FGF2 and the previously mapped complement I factor (IF).

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KW - Comparative mapping

KW - Genetic linkage

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Genetic mapping of five human chromosome 4 orthologues to bovine chromosomes 6 and 17

Abstract

Keywords

ASJC Scopus subject areas

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