Genetic assessment of environmental features that influence deer dispersal: Implications for prion-infected populations

Amy C. Kelly, Nohra E Mateus-Pinilla, William Brown, Marilyn Sue O'Hara, Marlis R. Douglas, Michael E. Douglas, Paul Shelton, Tom Beissel, Jan E Novakofski

Research output: Contribution to journalArticle

Abstract

The landscape can influence host dispersal and density, which in turn, affect infectious disease transmission, spread, and persistence. Understanding how the landscape influences wildlife dispersal and pathogen epidemiology can enhance the efficacy of disease management in natural populations. We applied landscape genetics to examine relationships among landscape variables, dispersal of white-tailed deer hosts and transmission/spread of chronic wasting disease (CWD), a fatal prion encephalopathy. Our focus was on quantifying movements and population structure of host deer in infected areas as a means of predicting the spread of this pathology and promoting its adaptive management. We analyzed microsatellite genotypes of CWD-infected and uninfected deer from two disease foci (Southern Wisconsin, Northern Illinois). We quantified gene flow and population structure using F ST, assignment tests, and spatial autocorrelation analyses. Gene flow estimates were then contrasted against a suite of landscape variables that potentially mediate deer dispersal. Forest fragmentation and grassland connectivity promoted deer movements while rivers, agricultural fields and large urbanized areas impeded movement. Landscape variables, deer dispersal, and disease transmission covaried significantly and positively in our analyses. Habitats with elevated host gene flow supported the concept of dispersal-mediated CWD transmission by reflecting a concomitant, rapid CWD expansion. Large, interrelated social groups isolated by movement barriers overlapped disease foci, suggesting that philopatry exacerbated CWD transmission. Our results promote adaptive management of CWD by predicting patterns of its spread and identifying habitats at risk for invasion. Further, our landscape genetics approach underscores the significance of topography and host behavior in wildlife disease transmission.

Original languageEnglish (US)
Pages (from-to)327-340
Number of pages14
JournalPopulation Ecology
Volume56
Issue number2
DOIs
StatePublished - Apr 2014

Fingerprint

chronic wasting disease
prions
environmental assessment
deer
disease transmission
gene flow
adaptive management
population structure
wildlife diseases
philopatry
encephalopathy
flow structure
infectious disease
habitat
Odocoileus virginianus
pathology
epidemiology
habitats
autocorrelation
habitat fragmentation

Keywords

  • Chronic wasting disease
  • Gene flow
  • Illinois
  • Isolation-by-distance
  • White-tailed deer
  • Wisconsin

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics

Cite this

Genetic assessment of environmental features that influence deer dispersal : Implications for prion-infected populations. / Kelly, Amy C.; Mateus-Pinilla, Nohra E; Brown, William; O'Hara, Marilyn Sue; Douglas, Marlis R.; Douglas, Michael E.; Shelton, Paul; Beissel, Tom; Novakofski, Jan E.

In: Population Ecology, Vol. 56, No. 2, 04.2014, p. 327-340.

Research output: Contribution to journalArticle

Kelly, Amy C. ; Mateus-Pinilla, Nohra E ; Brown, William ; O'Hara, Marilyn Sue ; Douglas, Marlis R. ; Douglas, Michael E. ; Shelton, Paul ; Beissel, Tom ; Novakofski, Jan E. / Genetic assessment of environmental features that influence deer dispersal : Implications for prion-infected populations. In: Population Ecology. 2014 ; Vol. 56, No. 2. pp. 327-340.
@article{055a545ab6514b2e9b79e87f92f39568,
title = "Genetic assessment of environmental features that influence deer dispersal: Implications for prion-infected populations",
abstract = "The landscape can influence host dispersal and density, which in turn, affect infectious disease transmission, spread, and persistence. Understanding how the landscape influences wildlife dispersal and pathogen epidemiology can enhance the efficacy of disease management in natural populations. We applied landscape genetics to examine relationships among landscape variables, dispersal of white-tailed deer hosts and transmission/spread of chronic wasting disease (CWD), a fatal prion encephalopathy. Our focus was on quantifying movements and population structure of host deer in infected areas as a means of predicting the spread of this pathology and promoting its adaptive management. We analyzed microsatellite genotypes of CWD-infected and uninfected deer from two disease foci (Southern Wisconsin, Northern Illinois). We quantified gene flow and population structure using F ST, assignment tests, and spatial autocorrelation analyses. Gene flow estimates were then contrasted against a suite of landscape variables that potentially mediate deer dispersal. Forest fragmentation and grassland connectivity promoted deer movements while rivers, agricultural fields and large urbanized areas impeded movement. Landscape variables, deer dispersal, and disease transmission covaried significantly and positively in our analyses. Habitats with elevated host gene flow supported the concept of dispersal-mediated CWD transmission by reflecting a concomitant, rapid CWD expansion. Large, interrelated social groups isolated by movement barriers overlapped disease foci, suggesting that philopatry exacerbated CWD transmission. Our results promote adaptive management of CWD by predicting patterns of its spread and identifying habitats at risk for invasion. Further, our landscape genetics approach underscores the significance of topography and host behavior in wildlife disease transmission.",
keywords = "Chronic wasting disease, Gene flow, Illinois, Isolation-by-distance, White-tailed deer, Wisconsin",
author = "Kelly, {Amy C.} and Mateus-Pinilla, {Nohra E} and William Brown and O'Hara, {Marilyn Sue} and Douglas, {Marlis R.} and Douglas, {Michael E.} and Paul Shelton and Tom Beissel and Novakofski, {Jan E}",
year = "2014",
month = "4",
doi = "10.1007/s10144-013-0427-9",
language = "English (US)",
volume = "56",
pages = "327--340",
journal = "Population Ecology",
issn = "1438-3896",
publisher = "Springer Japan",
number = "2",

}

TY - JOUR

T1 - Genetic assessment of environmental features that influence deer dispersal

T2 - Implications for prion-infected populations

AU - Kelly, Amy C.

AU - Mateus-Pinilla, Nohra E

AU - Brown, William

AU - O'Hara, Marilyn Sue

AU - Douglas, Marlis R.

AU - Douglas, Michael E.

AU - Shelton, Paul

AU - Beissel, Tom

AU - Novakofski, Jan E

PY - 2014/4

Y1 - 2014/4

N2 - The landscape can influence host dispersal and density, which in turn, affect infectious disease transmission, spread, and persistence. Understanding how the landscape influences wildlife dispersal and pathogen epidemiology can enhance the efficacy of disease management in natural populations. We applied landscape genetics to examine relationships among landscape variables, dispersal of white-tailed deer hosts and transmission/spread of chronic wasting disease (CWD), a fatal prion encephalopathy. Our focus was on quantifying movements and population structure of host deer in infected areas as a means of predicting the spread of this pathology and promoting its adaptive management. We analyzed microsatellite genotypes of CWD-infected and uninfected deer from two disease foci (Southern Wisconsin, Northern Illinois). We quantified gene flow and population structure using F ST, assignment tests, and spatial autocorrelation analyses. Gene flow estimates were then contrasted against a suite of landscape variables that potentially mediate deer dispersal. Forest fragmentation and grassland connectivity promoted deer movements while rivers, agricultural fields and large urbanized areas impeded movement. Landscape variables, deer dispersal, and disease transmission covaried significantly and positively in our analyses. Habitats with elevated host gene flow supported the concept of dispersal-mediated CWD transmission by reflecting a concomitant, rapid CWD expansion. Large, interrelated social groups isolated by movement barriers overlapped disease foci, suggesting that philopatry exacerbated CWD transmission. Our results promote adaptive management of CWD by predicting patterns of its spread and identifying habitats at risk for invasion. Further, our landscape genetics approach underscores the significance of topography and host behavior in wildlife disease transmission.

AB - The landscape can influence host dispersal and density, which in turn, affect infectious disease transmission, spread, and persistence. Understanding how the landscape influences wildlife dispersal and pathogen epidemiology can enhance the efficacy of disease management in natural populations. We applied landscape genetics to examine relationships among landscape variables, dispersal of white-tailed deer hosts and transmission/spread of chronic wasting disease (CWD), a fatal prion encephalopathy. Our focus was on quantifying movements and population structure of host deer in infected areas as a means of predicting the spread of this pathology and promoting its adaptive management. We analyzed microsatellite genotypes of CWD-infected and uninfected deer from two disease foci (Southern Wisconsin, Northern Illinois). We quantified gene flow and population structure using F ST, assignment tests, and spatial autocorrelation analyses. Gene flow estimates were then contrasted against a suite of landscape variables that potentially mediate deer dispersal. Forest fragmentation and grassland connectivity promoted deer movements while rivers, agricultural fields and large urbanized areas impeded movement. Landscape variables, deer dispersal, and disease transmission covaried significantly and positively in our analyses. Habitats with elevated host gene flow supported the concept of dispersal-mediated CWD transmission by reflecting a concomitant, rapid CWD expansion. Large, interrelated social groups isolated by movement barriers overlapped disease foci, suggesting that philopatry exacerbated CWD transmission. Our results promote adaptive management of CWD by predicting patterns of its spread and identifying habitats at risk for invasion. Further, our landscape genetics approach underscores the significance of topography and host behavior in wildlife disease transmission.

KW - Chronic wasting disease

KW - Gene flow

KW - Illinois

KW - Isolation-by-distance

KW - White-tailed deer

KW - Wisconsin

UR - http://www.scopus.com/inward/record.url?scp=84897039603&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897039603&partnerID=8YFLogxK

U2 - 10.1007/s10144-013-0427-9

DO - 10.1007/s10144-013-0427-9

M3 - Article

AN - SCOPUS:84897039603

VL - 56

SP - 327

EP - 340

JO - Population Ecology

JF - Population Ecology

SN - 1438-3896

IS - 2

ER -