Abstract
Insulin-like growth factor IGF-I and IGF-II gene expression was measured for the first time in rat liver, brain and heart during the later stages of life, i.e., young adulthood (6 months) to senescence (25 months). IGF-I mRNA was detected in all three tissues at all ages. Its relative level decreased the most in the liver with advancing age. IGF-II mRNA was detected in the brain and heart but not the liver at all ages. The level of IGF-II mRNA decreased only slightly in the brain from young adulthood to senescence.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 310-316 |
| Number of pages | 7 |
| Journal | Gerontology |
| Volume | 37 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 1991 |
Keywords
- Gene expression
- Insulin-like growth factors
- Senescent tissues
ASJC Scopus subject areas
- Aging
- Geriatrics and Gerontology