Genes for insulin-like growth factors I and II are expressed in senescent rat tissues

G. H. Park, D. E. Buetow

Research output: Contribution to journalArticlepeer-review

Abstract

Insulin-like growth factor IGF-I and IGF-II gene expression was measured for the first time in rat liver, brain and heart during the later stages of life, i.e., young adulthood (6 months) to senescence (25 months). IGF-I mRNA was detected in all three tissues at all ages. Its relative level decreased the most in the liver with advancing age. IGF-II mRNA was detected in the brain and heart but not the liver at all ages. The level of IGF-II mRNA decreased only slightly in the brain from young adulthood to senescence.

Original languageEnglish (US)
Pages (from-to)310-316
Number of pages7
JournalGerontology
Volume37
Issue number6
DOIs
StatePublished - Jan 1 1991

Keywords

  • Gene expression
  • Insulin-like growth factors
  • Senescent tissues

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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