@inproceedings{96d5dc53b6c642f0998213d278b0b4f1,
title = "Gene-Edited Live Cell Sensor for Free Calcium",
abstract = "A human cell line was gene-edited to provide a visually observable fluorescence response to extracellular free calcium using the CRISPR-Cas9 system. The developed sensor cells have a dynamic range of 0.01-10 μM, and the ability to be reused for multiple signal excitations. We envision using gene-edited cells as responsive elements within tissue engineered constructs that interface with the body for noninvasive semi-continuous monitoring of circulating analytes.",
keywords = "CRISPR-Cas9, calcium, live cell sensor",
author = "Fu Sun and Lee, {Dong Hoon} and Thomas Gaj and Cunningham, {Brian T.}",
note = "Publisher Copyright: {\textcopyright} 2019 IEEE.; 18th IEEE Sensors, SENSORS 2019 ; Conference date: 27-10-2019 Through 30-10-2019",
year = "2019",
month = oct,
doi = "10.1109/SENSORS43011.2019.8956634",
language = "English (US)",
series = "Proceedings of IEEE Sensors",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
booktitle = "2019 IEEE Sensors, SENSORS 2019 - Conference Proceedings",
address = "United States",
}