Gene delivery method using photo-responsive poly(β-amino ester) as vectors

Nan Zheng, Yang Liu, Jianjun Cheng

Research output: Chapter in Book/Report/Conference proceedingChapter


Nonviral vectors show great potential in delivering nucleic acids (NA) into many mammalian cells to achieve efficient gene transfection. Among these, cationic polymer is one of the most widely used nonviral gene delivery vectors, forming the polymer/NA complexes for the intracellular transportation and release of the genetic materials into the target mammalian cells. Here we describe the poly(β-amino ester) (PBAE) with the photo-responsive domain built in the polymers, as a UV-light-responsive nonviral gene delivery vector to deliver and release plasmid DNA (pDNA) into HeLa cells and achieve enhanced transfection efficiency.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages9
StatePublished - Jan 1 2016

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Nonviral gene delivery
  • Photo-responsive
  • Poly (β-amino ester)s
  • Transfection efficiency

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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