Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis

Andrew J. Steelman, Roger Smith, C. Jane Welsh, Jianrong Li

Research output: Contribution to journalArticle

Abstract

Background: Galectins are increased in astrocytes of patients with multiple sclerosis. Results: TNF up-regulates galectin-9 in primary astrocytes via the TNFR1/JNK/c-Jun pathway and can induce apoptosis of encephalitogenic T-cells. Conclusion: Astrocytes up-regulate galectin-9 in response to the proinflammatory cytokine TNF. Significance: Astrocyte-derived galectin-9 may function to restrict encephalitogenic T-cell-mediated inflammation in the CNS.

Original languageEnglish (US)
Pages (from-to)23776-23787
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number33
DOIs
StatePublished - Aug 16 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis'. Together they form a unique fingerprint.

  • Cite this