GABAA receptor subtypes: Dissecting their pharmacological functions

Uwe Rudolph, Florence Crestani, Hanns Möhler

Research output: Contribution to journalReview articlepeer-review

Abstract

The enhancement of GABA-mediated synaptic transmission underlies the pharmacotherapy of various neurological and psychiatric disorders. GABAA receptors are pluripotent drug targets that display an extraordinary structural heterogeneity: they are assembled from a repertoire of at least 18 subunits (α1-6, β1-3, γ1-3, δ, ε, θ, ρ1-3). However, differentiating defined GABAA receptor subtypes on the basis of function has had to await recent progress in the genetic dissection of receptor subtypes in vivo. Evidence that the various actions of allosteric modulators of GABAA receptors, in particular the benzodiazepines, can be attributed to specific GABAA receptor subtypes will be discussed. Such discoveries could open up new avenues for drug development.

Original languageEnglish (US)
Pages (from-to)188-194
Number of pages7
JournalTrends in Pharmacological Sciences
Volume22
Issue number4
DOIs
StatePublished - Apr 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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