GABA(A)-receptor assembly in vivo: Lessons from subunit mutant mice

H. Mohler, B. Luscher, J. M. Fritschy, D. Benke, J. Benson, U. Rudolph

Research output: Contribution to journalArticlepeer-review

Abstract

The rules governing the assembly of GABA(A) receptors in vivo were assessed in subunit mutant mice. The transcription of individual subunit genes was regulated independently. The lack of a particular subunit did not result in a molecular rescue by an enhanced transcription of other subunits. In addition, the availability of an α- and β-subunit was essential for receptor formation. Finally, highly selective recognition processes directed the subcellular targeting of receptors. The loss of a particular receptor subtype (α5) did not lead to a subcellular redistribution of the remaining subtype (α2) present in the same cell.

Original languageEnglish (US)
Pages (from-to)1611-1615
Number of pages5
JournalLife Sciences
Volume62
Issue number17-18
DOIs
StatePublished - Mar 27 1998
Externally publishedYes

Keywords

  • GABA(A)-receptor subtype
  • Gene transcription
  • Subcellular targeting

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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