G protein-coupled receptors in Anopheles gambiae

Catherine A. Hill, A. Nicole Fox, R. Jason Pitts, Lauren B. Kent, Perciliz L. Tan, Mathew A. Chrystal, Anibal Cravchik, Frank H. Collins, Hugh M. Robertson, Laurence J. Zwiebel

Research output: Contribution to journalArticle

Abstract

We used bioinformatic approaches to identify a total of 276 G protein-coupled receptors (GPCRs) from the Anopheles gambiae genome. These include GPCRs that are likely to play roles in pathways affecting almost every aspect of the mosquito's life cycle. Seventy-nine candidate odorant receptors were characterized for tissue expression and, along with 76 putative gustatory receptors, for their molecular evolution relative to Drosophila melanogaster. Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation.

Original languageEnglish (US)
Pages (from-to)176-178
Number of pages3
JournalScience
Volume298
Issue number5591
DOIs
StatePublished - Oct 4 2002
Externally publishedYes

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    Hill, C. A., Fox, A. N., Pitts, R. J., Kent, L. B., Tan, P. L., Chrystal, M. A., Cravchik, A., Collins, F. H., Robertson, H. M., & Zwiebel, L. J. (2002). G protein-coupled receptors in Anopheles gambiae. Science, 298(5591), 176-178. https://doi.org/10.1126/science.1076196