Furans with basic side chains: Synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha

Deborah S. Mortensen, Alice L. Rodriguez, Jun Sun, Benita S. Katzenellenbogen, John A. Katzenellenbogen

Research output: Contribution to journalArticle

Abstract

3-Alkyl-2,4,5-triarylfurans with basic side-chain substituents were prepared as ligands for the estrogen receptor. Those analogues having the basic side chain on the C(4) phenol were high-affinity, ERα-selective antagonists.

Original languageEnglish (US)
Pages (from-to)2521-2524
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number18
DOIs
StatePublished - Sep 17 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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