TY - JOUR
T1 - Furans with basic side chains
T2 - Synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha
AU - Mortensen, Deborah S.
AU - Rodriguez, Alice L.
AU - Sun, Jun
AU - Katzenellenbogen, Benita S.
AU - Katzenellenbogen, John A.
N1 - Funding Information:
We are grateful for support of this research through grants from the National Institutes of Health, the US Army, and the NSF and Keck Foundation. We thank Kathryn Carlson for excellent assistance.
PY - 2001/9/17
Y1 - 2001/9/17
N2 - 3-Alkyl-2,4,5-triarylfurans with basic side-chain substituents were prepared as ligands for the estrogen receptor. Those analogues having the basic side chain on the C(4) phenol were high-affinity, ERα-selective antagonists.
AB - 3-Alkyl-2,4,5-triarylfurans with basic side-chain substituents were prepared as ligands for the estrogen receptor. Those analogues having the basic side chain on the C(4) phenol were high-affinity, ERα-selective antagonists.
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U2 - 10.1016/S0960-894X(01)00488-7
DO - 10.1016/S0960-894X(01)00488-7
M3 - Article
C2 - 11549460
AN - SCOPUS:0035903872
SN - 0960-894X
VL - 11
SP - 2521
EP - 2524
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 18
ER -