Abstract
Members of the B'/B56/PR61 family regulatory subunits of PP2A determine the subcellular localization, substrate specificity, and catalytic activity of PP2A in a wide range of biological processes. Here, we summarize the structure and intracellular localization of B56-containing PP2As and review functions of B56-containing PP2As in several major developmental/cancer signaling pathways.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 659-666 |
| Number of pages | 8 |
| Journal | Life Sciences |
| Volume | 87 |
| Issue number | 23-26 |
| DOIs | |
| State | Published - Dec 18 2010 |
| Externally published | Yes |
Keywords
- B'
- B56
- Development
- PP2A
- PR61
- Regulatory subunit
- Signaling pathways
- Tumorigenesis
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Pharmacology, Toxicology and Pharmaceutics