Functions of B56-containing PP2As in major developmental and cancer signaling pathways

Jing Yang; Christopher Phiel

doi:10.1016/j.lfs.2010.10.003

Functions of B56-containing PP2As in major developmental and cancer signaling pathways

Jing Yang, Christopher Phiel

Research output: Contribution to journal › Review article › peer-review

Abstract

Members of the B'/B56/PR61 family regulatory subunits of PP2A determine the subcellular localization, substrate specificity, and catalytic activity of PP2A in a wide range of biological processes. Here, we summarize the structure and intracellular localization of B56-containing PP2As and review functions of B56-containing PP2As in several major developmental/cancer signaling pathways.

Original language	English (US)
Pages (from-to)	659-666
Number of pages	8
Journal	Life Sciences
Volume	87
Issue number	23-26
DOIs	https://doi.org/10.1016/j.lfs.2010.10.003
State	Published - Dec 18 2010
Externally published	Yes

Keywords

B'
B56
Development
PP2A
PR61
Regulatory subunit
Signaling pathways
Tumorigenesis

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/j.lfs.2010.10.003

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Cite this

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title = "Functions of B56-containing PP2As in major developmental and cancer signaling pathways",

abstract = "Members of the B'/B56/PR61 family regulatory subunits of PP2A determine the subcellular localization, substrate specificity, and catalytic activity of PP2A in a wide range of biological processes. Here, we summarize the structure and intracellular localization of B56-containing PP2As and review functions of B56-containing PP2As in several major developmental/cancer signaling pathways.",

keywords = "B', B56, Development, PP2A, PR61, Regulatory subunit, Signaling pathways, Tumorigenesis",

author = "Jing Yang and Christopher Phiel",

note = "Funding Information: JY is supported by grant 1R01GM093217-01A1 from NIGMS . CP is supported by grant 1R01AG031833 from NIA .",

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doi = "10.1016/j.lfs.2010.10.003",

language = "English (US)",

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AU - Yang, Jing

AU - Phiel, Christopher

N1 - Funding Information: JY is supported by grant 1R01GM093217-01A1 from NIGMS . CP is supported by grant 1R01AG031833 from NIA .

PY - 2010/12/18

Y1 - 2010/12/18

N2 - Members of the B'/B56/PR61 family regulatory subunits of PP2A determine the subcellular localization, substrate specificity, and catalytic activity of PP2A in a wide range of biological processes. Here, we summarize the structure and intracellular localization of B56-containing PP2As and review functions of B56-containing PP2As in several major developmental/cancer signaling pathways.

AB - Members of the B'/B56/PR61 family regulatory subunits of PP2A determine the subcellular localization, substrate specificity, and catalytic activity of PP2A in a wide range of biological processes. Here, we summarize the structure and intracellular localization of B56-containing PP2As and review functions of B56-containing PP2As in several major developmental/cancer signaling pathways.

KW - B'

KW - B56

KW - Development

KW - PP2A

KW - PR61

KW - Regulatory subunit

KW - Signaling pathways

KW - Tumorigenesis

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DO - 10.1016/j.lfs.2010.10.003

M3 - Review article

C2 - 20934435

AN - SCOPUS:78649448708

VL - 87

SP - 659

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JO - Life Sciences

JF - Life Sciences

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