Functions of B56-containing PP2As in major developmental and cancer signaling pathways

Jing Yang, Christopher Phiel

Research output: Contribution to journalReview articlepeer-review

Abstract

Members of the B'/B56/PR61 family regulatory subunits of PP2A determine the subcellular localization, substrate specificity, and catalytic activity of PP2A in a wide range of biological processes. Here, we summarize the structure and intracellular localization of B56-containing PP2As and review functions of B56-containing PP2As in several major developmental/cancer signaling pathways.

Original languageEnglish (US)
Pages (from-to)659-666
Number of pages8
JournalLife Sciences
Volume87
Issue number23-26
DOIs
StatePublished - Dec 18 2010
Externally publishedYes

Keywords

  • B'
  • B56
  • Development
  • PP2A
  • PR61
  • Regulatory subunit
  • Signaling pathways
  • Tumorigenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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