Functionalized ultrathin palladium nanosheets as patches for HepG2 cancer cells

Yung Tin Pan, Cartney E. Smith, Kam Sang Kwok, Jinrong Chen, Hyunjoon Kong, Hong Yang

Research output: Contribution to journalArticlepeer-review


Flexible, charged Pd nanosheets were prepared by using short chain thiolated carboxylic acids and amines. They could wrap around amine or hydroxyl functionalized micron-sized spheres driven by electrostatic interactions. Upon incubation with HepG2 cells, the positively charged cysteamine (CA) functionalized Pd nanosheets exhibited a much higher cytotoxicity, showing more than 80% cell death at 100 ppm than the negatively charged 3-mercaptopropionic acid (MPA) functionalized ones which caused 30% cell death. The results show through surface functionalization Pd nanosheets can be modified to interact differently with HepG2 cancerous cells, resulting in varied cytotoxicity.

Original languageEnglish (US)
Pages (from-to)14171-14174
Number of pages4
JournalChemical Communications
Issue number75
StatePublished - Jul 31 2015

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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