Functionalized, long-circulating, and ultrasmall gold nanocarriers for overcoming the barriers of low nanoparticle delivery efficiency and poor tumor penetration

Keyphrases

• Ultrasmall 100%
• Tumor Penetration 100%
• Delivery Efficiency 100%
• Nanoparticle Delivery 100%
• Long-circulating 100%
• Gold Nanocarriers 100%
• Doxorubicin 66%
• Nanoparticles 66%
• Therapeutic Efficacy 66%
• PH-sensitive 33%
• Hydrazone Linkage 33%
• Tumor 33%
• Drug Delivery 33%
• Targeted Delivery 33%
• Vital Organs 33%
• Injected Dose 33%
• Therapeutic Agents 33%
• Solid Tumors 33%
• Nanoparticle Diffusion 33%
• Tumor Mass 33%
• Visual Inspection 33%
• Nanoplatform 33%
• Gold Core 33%
• Intracellular Organelles 33%
• Hydrodynamic Radius 33%
• Functionalized Gold Nanoparticles 33%
• Animal Data 33%
• Permeability Effect 33%
• Enhanced Permeability 33%
• Enhanced Retention 33%
• Retention Effect 33%
• Basic pH 33%
• Tumor Site 33%
• Heart-lung 33%
• Small Particle Size 33%
• Systemic Toxicity 33%
• Nanoparticle Distribution 33%
• Heart-kidney 33%
• Kidney Toxicity 33%
• Toxicity in Vivo 33%
• Ultrasmall Gold Nanoparticles 33%
• Acidic Tumor Microenvironment 33%
• Nanoparticle Penetration 33%
• Deep Tumor Penetration 33%
• Xenograft Animal Model 33%
• Lung Toxicity 33%
• Heart Toxicity 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Nanocarrier 100%
• Nanoparticle 100%
• Neoplasm 100%
• Doxorubicin 28%
• Combination Therapy 28%
• Hydrazone Derivative 14%
• Gold Nanoparticle 14%
• Solid Malignant Neoplasm 14%
• Extravasation 14%
• Tumor Microenvironment 14%
• Enhanced Permeability and Retention Effect 14%
• Nephrotoxicity 14%
• Lung Toxicity 14%
• Cardiotoxicity 14%