Functionalization of Carbon Nanotubes for Biocompatibility and Biomolecular Recognition

Moonsub Shim, Nadine Wong Shi Kam, Robert J. Chen, Yiming Li, Hongjie Dai

Research output: Contribution to journalArticlepeer-review


The interface between biological molecules and novel nanomaterials is important to developing new types of miniature devices for biological applications. Here, the streptavidin/biotin system is used to investigate the adsorption behavior of proteins on the sides of single-walled carbon nanotubes (SWNTs). Functionalization of SWNTs by coadsorption of a surfactant and poly(ethylene glycol) is found to be effective in resisting nonspecific adsorption of streptavidin. Specific binding of streptavidin onto SWNTs is achieved by co-functionalization of nanotubes with biotin and protein-resistant polymers.

Original languageEnglish (US)
Pages (from-to)285-288
Number of pages4
JournalNano letters
Issue number4
StatePublished - Apr 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering


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