Functionalization of Carbon Nanotubes for Biocompatibility and Biomolecular Recognition

Moonsub Shim; Nadine Wong Shi Kam; Robert J. Chen; Yiming Li; Hongjie Dai

doi:10.1021/nl015692j

Functionalization of Carbon Nanotubes for Biocompatibility and Biomolecular Recognition

Moonsub Shim, Nadine Wong Shi Kam, Robert J. Chen, Yiming Li, Hongjie Dai

Research output: Contribution to journal › Article › peer-review

Abstract

The interface between biological molecules and novel nanomaterials is important to developing new types of miniature devices for biological applications. Here, the streptavidin/biotin system is used to investigate the adsorption behavior of proteins on the sides of single-walled carbon nanotubes (SWNTs). Functionalization of SWNTs by coadsorption of a surfactant and poly(ethylene glycol) is found to be effective in resisting nonspecific adsorption of streptavidin. Specific binding of streptavidin onto SWNTs is achieved by co-functionalization of nanotubes with biotin and protein-resistant polymers.

Original language	English (US)
Pages (from-to)	285-288
Number of pages	4
Journal	Nano letters
Volume	2
Issue number	4
DOIs	https://doi.org/10.1021/nl015692j
State	Published - Apr 1 2002
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
Chemistry(all)
Materials Science(all)
Condensed Matter Physics
Mechanical Engineering

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abstract = "The interface between biological molecules and novel nanomaterials is important to developing new types of miniature devices for biological applications. Here, the streptavidin/biotin system is used to investigate the adsorption behavior of proteins on the sides of single-walled carbon nanotubes (SWNTs). Functionalization of SWNTs by coadsorption of a surfactant and poly(ethylene glycol) is found to be effective in resisting nonspecific adsorption of streptavidin. Specific binding of streptavidin onto SWNTs is achieved by co-functionalization of nanotubes with biotin and protein-resistant polymers.",

author = "Moonsub Shim and Kam, {Nadine Wong Shi} and Chen, {Robert J.} and Yiming Li and Hongjie Dai",

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AU - Chen, Robert J.

AU - Li, Yiming

AU - Dai, Hongjie

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AB - The interface between biological molecules and novel nanomaterials is important to developing new types of miniature devices for biological applications. Here, the streptavidin/biotin system is used to investigate the adsorption behavior of proteins on the sides of single-walled carbon nanotubes (SWNTs). Functionalization of SWNTs by coadsorption of a surfactant and poly(ethylene glycol) is found to be effective in resisting nonspecific adsorption of streptavidin. Specific binding of streptavidin onto SWNTs is achieved by co-functionalization of nanotubes with biotin and protein-resistant polymers.

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