@inproceedings{90a997685d454dc78ebe83ed57f6c0bd,
title = "Functional significance of Alzheimer specific changes in chromatin structure",
abstract = "Many pathogenic factors including viruses and carcinogens may change chromatin structure and induce heterochromatization. Our data indicate that among the neurodegenerative diseases of the human cerebral cortex, only AD affects the distribution of the methionine containing histone H1 1°. The defect in expression of the NF-L gene may only be one of several important genes necessary for normal neuron function and survival which is affected by this mechanism. The actual failure within neurons could involve one of many mechanisms including detoxification of free radicals, calcium buffering or osmotic regulation. Whatever the mechanisms responsible for neuron dysfunction and death, a more effective therapeutic strategy is to identify and prevent the cascade of events which result in failure of neuron homeostasis rather than attempt to treat one aspect of neuron failure, such as loss of a neurotransmitter.",
author = "McLachlan, {D. R.C.} and Mizzen, {C. A.} and Lukiw, {W. J.} and Somerville, {M. J.} and Sutherland, {M. K.} and C. Bergeron and L. Wong and L. Tabarrok and Percy, {M. E.}",
year = "1990",
month = jan,
day = "1",
language = "English (US)",
isbn = "0444811125",
series = "Molecular biology and genetics of Alzheimer's disease: proceedings of the International Symposium on Dementia: Molecular Biology and Genetics of Alzheimer's Disease. ICS884",
publisher = "Elsevier Science Publishers B.V.",
pages = "255--265",
editor = "T. Miyatake and D.J. Selkoe and Y. Ihara and T. Miyatake and D.J. Selkoe and Y. Ihara",
booktitle = "Molecular biology and genetics of Alzheimer's disease",
note = "The International Symposium on Dementia: Molecular Biology and Genetics of Alzheimer's Disease ; Conference date: 11-11-1989 Through 14-11-1989",
}