Functional significance of Alzheimer specific changes in chromatin structure

D. R.C. McLachlan, C. A. Mizzen, W. J. Lukiw, M. J. Somerville, M. K. Sutherland, C. Bergeron, L. Wong, L. Tabarrok, M. E. Percy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Many pathogenic factors including viruses and carcinogens may change chromatin structure and induce heterochromatization. Our data indicate that among the neurodegenerative diseases of the human cerebral cortex, only AD affects the distribution of the methionine containing histone H1 1°. The defect in expression of the NF-L gene may only be one of several important genes necessary for normal neuron function and survival which is affected by this mechanism. The actual failure within neurons could involve one of many mechanisms including detoxification of free radicals, calcium buffering or osmotic regulation. Whatever the mechanisms responsible for neuron dysfunction and death, a more effective therapeutic strategy is to identify and prevent the cascade of events which result in failure of neuron homeostasis rather than attempt to treat one aspect of neuron failure, such as loss of a neurotransmitter.

Original languageEnglish (US)
Title of host publicationMolecular biology and genetics of Alzheimer's disease
Subtitle of host publicationproceedings of the International Symposium on Dementia: Molecular Biology and Genetics of Alzheimer's Disease. ICS884
EditorsT. Miyatake, D.J. Selkoe, Y. Ihara, T. Miyatake, D.J. Selkoe, Y. Ihara
PublisherElsevier Science Publishers B.V.
Pages255-265
Number of pages11
ISBN (Print)0444811125
StatePublished - Jan 1 1990
EventThe International Symposium on Dementia: Molecular Biology and Genetics of Alzheimer's Disease -
Duration: Nov 11 1989Nov 14 1989

Publication series

NameMolecular biology and genetics of Alzheimer's disease: proceedings of the International Symposium on Dementia: Molecular Biology and Genetics of Alzheimer's Disease. ICS884

Other

OtherThe International Symposium on Dementia: Molecular Biology and Genetics of Alzheimer's Disease
Period11/11/8911/14/89

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Functional significance of Alzheimer specific changes in chromatin structure'. Together they form a unique fingerprint.

Cite this