Functional insights into the role of nuclear-retained long noncoding RNAs in gene expression control in mammalian cells

Deepak K. Singh, Kannanganattu V. Prasanth

Research output: Contribution to journalReview article

Abstract

The mammalian genome harbors thousands of long noncoding RNA (lncRNA) genes. Recent studies have indicated the involvement of several of these lncRNAs in the regulation of gene expression. lncRNAs play crucial roles in various biological processes ranging from epigenetic gene regulation, transcriptional control, to post-transcriptional regulation. lncRNAs are localized in various subcellular compartments, and major proportion of these are retained in the cell nucleus and could be broadly classified as nuclear-retained lncRNAs (nrRNAs). Based on the identified functions, members of the nrRNAs execute diverse roles, including providing architectural support to the hierarchical subnuclear organization and influencing the recruitment of chromatin modifier factors to specific chromatin sites. In this review, we will summarize the recently described roles of mammalian nrRNAs in controlling gene expression by influencing chromatin organization, transcription, pre-mRNA processing, nuclear organization, and their involvement in disease.

Original languageEnglish (US)
Pages (from-to)695-711
Number of pages17
JournalChromosome Research
Volume21
Issue number6-7
DOIs
StatePublished - Dec 1 2013

Keywords

  • Cell cycle
  • Chromatin remodeling
  • Long noncoding RNA
  • MALAT1
  • Nuclear domains
  • Nuclear-retained ncRNA
  • Pre-mRNA splicing

ASJC Scopus subject areas

  • Genetics

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