Functional imaging with FENSI: Flow-enhanced signal intensity

Bradley P. Sutton, Cheng Ouyang, Bryce L. Ching, Luisa Ciobanu

Research output: Contribution to journalArticlepeer-review

Abstract

Flow measurement methods for functional MRI (fMRI) are desirable as they are more closely tied to neuronal activity than the commonly used blood oxygenation techniques. In this work we introduce a flow-based functional imaging method. The method, called flow enhancement of signal intensity (FENSI), is an extension of the diffusion enhancement of signal and resolution (DESIRE) method from MR microscopy. The FENSI method offers a localized flow-weighted signal across a very thin slice (0.4 mm in this study) that provides a signal enhancement that is dependent on the velocity and direction of the flow. The FENSI method was implemented on a human 3 T system and applied to a blocked visual cognitive task. Activation maps showed good localization and the measured signal changes of around 10% were in good agreement with the predicted enhancements.

Original languageEnglish (US)
Pages (from-to)396-401
Number of pages6
JournalMagnetic Resonance in Medicine
Volume58
Issue number2
DOIs
StatePublished - Aug 2007

Keywords

  • Cerebral blood flow
  • DESIRE
  • Functional MRI
  • Saturation
  • Signal enhancement

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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