Functional Genomics of P450s

Mary A. Schuler, Daniele Werck-Reichhart

Research output: Contribution to journalReview articlepeer-review


Plant systems utilize a diverse array of cytochrome P450 monooxygenases (P450s) in their biosynthetic and detoxicative pathways. Those P450s in biosynthetic pathways play critical roles in the synthesis of lignins, UV protectants, pigments, defense compounds, fatty acids, hormones, and signaling molecules. Those in catabolic pathways participate in the breakdown of endogenous compounds and toxic compounds encountered in the environment. Because of their roles in this wide diversity of metabolic processes, plant P450 proteins and transcripts can serve as downstream reporters for many different biochemical pathways responding to chemical, developmental, and environmental cues. This review focuses initially on defining P450 biochemistries, nomenclature systems, and the relationships between genes in the extended P450 superfamily that exists in all plant species. Subsequently, it focuses on outlining the many approaches being used to assign function to individual P450 proteins and gene loci. The examples of assigned P450 activities that are spread throughout this review highlight the importance of understanding and utilizing P450 sequences as markers for linking biochemical pathway responses to physiological processes.

Original languageEnglish (US)
Pages (from-to)629-667
Number of pages39
JournalAnnual Review of Plant Biology
StatePublished - 2003


  • Cytochrome P450 monooxygenases
  • Gene expression
  • Microarrays
  • Mutants
  • Oligonucleotide arrays
  • Plant biochemistry

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Plant Science
  • Cell Biology


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