TY - JOUR
T1 - Functional DNA nanotechnology
T2 - emerging applications of DNAzymes and aptamers
AU - Lu, Yi
AU - Liu, Juewen
N1 - Funding Information:
Research by the Lu group reviewed in this article is based upon work supported by the Department of Energy through an Environmental Remediation Sciences Program (DE-FG02-01ER63179), the National Science Foundation through a Nanoscale Science and Engineering Center grant (DMR-0117792), the US Army Research Laboratory and the US Army Research Office under grant number DAAD19-03-1-0227, and by the Illinois Waste Management Research Center under Contract number HWR04187.
PY - 2006/12
Y1 - 2006/12
N2 - In the past 25 years, DNA molecules have been utilized both as powerful synthetic building blocks to create nanoscale architectures and as versatile programmable templates for assembly of nanomaterials. In parallel, the functions of DNA molecules have been expanded from pure genetic information storage to catalytic functions like those of protein enzymes (DNAzymes) and specific binding functions like antibodies (aptamers). In the past few years, a new interdisciplinary field has emerged that aims to combine functional DNA biology with nanotechnology to generate more dynamic and controllable DNA-based nanostructures or DNA-templated nanomaterials that are responsive to chemical stimuli.
AB - In the past 25 years, DNA molecules have been utilized both as powerful synthetic building blocks to create nanoscale architectures and as versatile programmable templates for assembly of nanomaterials. In parallel, the functions of DNA molecules have been expanded from pure genetic information storage to catalytic functions like those of protein enzymes (DNAzymes) and specific binding functions like antibodies (aptamers). In the past few years, a new interdisciplinary field has emerged that aims to combine functional DNA biology with nanotechnology to generate more dynamic and controllable DNA-based nanostructures or DNA-templated nanomaterials that are responsive to chemical stimuli.
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U2 - 10.1016/j.copbio.2006.10.004
DO - 10.1016/j.copbio.2006.10.004
M3 - Review article
C2 - 17056247
AN - SCOPUS:33751247017
SN - 0958-1669
VL - 17
SP - 580
EP - 588
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
IS - 6
ER -