Functional DNA nanotechnology: emerging applications of DNAzymes and aptamers

Yi Lu, Juewen Liu

Research output: Contribution to journalReview articlepeer-review


In the past 25 years, DNA molecules have been utilized both as powerful synthetic building blocks to create nanoscale architectures and as versatile programmable templates for assembly of nanomaterials. In parallel, the functions of DNA molecules have been expanded from pure genetic information storage to catalytic functions like those of protein enzymes (DNAzymes) and specific binding functions like antibodies (aptamers). In the past few years, a new interdisciplinary field has emerged that aims to combine functional DNA biology with nanotechnology to generate more dynamic and controllable DNA-based nanostructures or DNA-templated nanomaterials that are responsive to chemical stimuli.

Original languageEnglish (US)
Pages (from-to)580-588
Number of pages9
JournalCurrent Opinion in Biotechnology
Issue number6
StatePublished - Dec 2006

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering


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