Functional CpG methylation system in a social insect

Ying Wang, Mireia Jorda, Peter L. Jones, Rjrszard Maleszka, Xu Ling, Hugh M. Robertson, Craig A. Mizzen, Miguel A. Peinado, Gene E. Robinson

Research output: Contribution to journalArticle

Abstract

DNA methylation systems are well characterized in vertebrates, but methylation in Drosophila melanogoster and other invertebrates remains controversial. Using the recently sequenced honey bee genome, we present a bioinformatic, molecular, and biochemical characterization of a functional DNA methylation system in an insect. We report on catalytically active orthologs of the vertebrate DNA methyltransferases Dnmt1 and Dnmt3a and b, two isoforms that contain a methyl-DNA binding domain, genomic 5-methyl-deoxycytosine, and CpG-methylated genes. The honey bee provides an opportunity to study the roles of methylation in social contexts.

Original languageEnglish (US)
Pages (from-to)645-647
Number of pages3
JournalScience
Volume314
Issue number5799
DOIs
StatePublished - Oct 27 2006

ASJC Scopus subject areas

  • General

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    Wang, Y., Jorda, M., Jones, P. L., Maleszka, R., Ling, X., Robertson, H. M., Mizzen, C. A., Peinado, M. A., & Robinson, G. E. (2006). Functional CpG methylation system in a social insect. Science, 314(5799), 645-647. https://doi.org/10.1126/science.1135213