Functional CpG methylation system in a social insect

Ying Wang, Mireia Jorda, Peter L. Jones, Rjrszard Maleszka, Xu Ling, Hugh M. Robertson, Craig A. Mizzen, Miguel A. Peinado, Gene E. Robinson

Research output: Contribution to journalArticle

Abstract

DNA methylation systems are well characterized in vertebrates, but methylation in Drosophila melanogoster and other invertebrates remains controversial. Using the recently sequenced honey bee genome, we present a bioinformatic, molecular, and biochemical characterization of a functional DNA methylation system in an insect. We report on catalytically active orthologs of the vertebrate DNA methyltransferases Dnmt1 and Dnmt3a and b, two isoforms that contain a methyl-DNA binding domain, genomic 5-methyl-deoxycytosine, and CpG-methylated genes. The honey bee provides an opportunity to study the roles of methylation in social contexts.

Original languageEnglish (US)
Pages (from-to)645-647
Number of pages3
JournalScience
Volume314
Issue number5799
DOIs
StatePublished - Oct 27 2006

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Honey
Bees
DNA Methylation
Methylation
Insects
Vertebrates
DNA
Methyltransferases
Invertebrates
Computational Biology
Drosophila
Protein Isoforms
Genome
Genes

ASJC Scopus subject areas

  • General

Cite this

Functional CpG methylation system in a social insect. / Wang, Ying; Jorda, Mireia; Jones, Peter L.; Maleszka, Rjrszard; Ling, Xu; Robertson, Hugh M.; Mizzen, Craig A.; Peinado, Miguel A.; Robinson, Gene E.

In: Science, Vol. 314, No. 5799, 27.10.2006, p. 645-647.

Research output: Contribution to journalArticle

Wang, Y, Jorda, M, Jones, PL, Maleszka, R, Ling, X, Robertson, HM, Mizzen, CA, Peinado, MA & Robinson, GE 2006, 'Functional CpG methylation system in a social insect', Science, vol. 314, no. 5799, pp. 645-647. https://doi.org/10.1126/science.1135213
Wang Y, Jorda M, Jones PL, Maleszka R, Ling X, Robertson HM et al. Functional CpG methylation system in a social insect. Science. 2006 Oct 27;314(5799):645-647. https://doi.org/10.1126/science.1135213
Wang, Ying ; Jorda, Mireia ; Jones, Peter L. ; Maleszka, Rjrszard ; Ling, Xu ; Robertson, Hugh M. ; Mizzen, Craig A. ; Peinado, Miguel A. ; Robinson, Gene E. / Functional CpG methylation system in a social insect. In: Science. 2006 ; Vol. 314, No. 5799. pp. 645-647.
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