Full-wave iterative image reconstruction in photoacoustic tomography with acoustically inhomogeneous media

Chao Huang, Kun Wang, Liming Nie, Lihong V. Wang, Mark A. Anastasio

Research output: Contribution to journalArticlepeer-review


Existing approaches to image reconstruction in photoacoustic computed tomography (PACT) with acoustically heterogeneous media are limited to weakly varying media, are computationally burdensome, and/or cannot effectively mitigate the effects of measurement data incompleteness and noise. In this work, we develop and investigate a discrete imaging model for PACT that is based on the exact photoacoustic (PA) wave equation and facilitates the circumvention of these limitations. A key contribution of the work is the establishment of a procedure to implement a matched forward and backprojection operator pair associated with the discrete imaging model, which permits application of a wide-range of modern image reconstruction algorithms that can mitigate the effects of data incompleteness and noise. The forward and backprojection operators are based on the k-space pseudospectral method for computing numerical solutions to the PA wave equation in the time domain. The developed reconstruction methodology is investigated by use of both computer-simulated and experimental PACT measurement data.

Original languageEnglish (US)
Article number6484982
Pages (from-to)1097-1110
Number of pages14
JournalIEEE transactions on medical imaging
Issue number6
StatePublished - 2013
Externally publishedYes


  • Acoustic heterogeneity
  • iterative image reconstruction
  • optoacoustic tomography
  • photoacoustic tomography
  • thermoacoustic tomography

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering


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