The operation of laminar flow-based fuel cells (LFFC) with formic acid, methanol, hydrazine, sodium borohydride, and ethanol as the fuel was studied. The performance of LFFC operating with alcohol-based fuels in acidic as well as alkaline media was demonstrated. The catalyst performance in microfluidic hydrogen fuel cells in which an acidic or alkaline stream was used as a flowing electrolyte was analyzed. The hydrogen fuel cell performance was compared using inexpensive non-Pt catalysts such as Ag-based cathodes instead of expensive Pt-catalysts with a flowing alkaline stream as the electrolyte. The fuel and media flexibility of microfluidic fuel cells was demonstrated. This is an abstract of a paper presented at the AIChE Annual Meeting (Salt Lake City, UT 11/4-9/2007).