There has been significant progress recognizing the value of Intelligence, Surveillance, and Reconnaissance (ISR) activities supporting Situational Awareness and Command and Control functions during the past several decades. We consider ISR operations to be proactive (discovering activities or areas of interest), active (activities performed for a particular task that flows down from a hierarchical process) or reactive (critical information gathering due to unexpected events). ISR synchronization includes the analysis and prioritization of information requirements, identification of intelligence gaps and the recommendation of available resources to gather information of interest, for all types of ISR operations. It has become critically important to perform synchronized ISR activities to maximize the efficient utilization of limited resources (both in quantity and capabilities) and, simultaneously, to increase the accuracy and timeliness of the information gain. A study evaluating the existing technologies and processes supporting ISR activities is performed suggesting a rigorous system optimization approach to the ISR synchronization process. Unfortunately, this approach is not used today. The study identifies existing gaps between the current ISR synchronization process and the proposed system optimization approach in the areas of communication and collaboration tools and advanced decision aids (analytics). Solutions are recommended that will help close this gap.