TY - JOUR
T1 - From infancy to aging
T2 - Biological and behavioral modifiers of Fetuin-A
AU - Robinson, Katie N.
AU - Teran-Garcia, Margarita
N1 - Funding Information:
Katie Robinson is supported by the National Institute for Agriculture U.S. Department of Agriculture, under award number 2011-67001-30101 for the Illinois Transdisciplinary Obesity Prevention Program to the Division of Nutritional Sciences at the University of Illinois. Margarita Teran-Garcia is supported by the National Institute for Agriculture under award number ILLU-689-312. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the U.S. Department of Agriculture.
Publisher Copyright:
© 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Fetuin-A is a multifunctional protein which inhibits ectopic calcification and insulin receptor phosphorylation. It may also promote insulin resistance by activation of toll-like receptor 4 pro-inflammatory cascade. Increased levels of Fetuin-A have been associated with obesity and related comorbidities such as type 2 diabetes and cardiovascular disease, therefore, it has been suggested as a potential therapeutic target for intervention. However, in addition to its role in disease pathophysiology, Fetuin-A is also important for growth and development. Thus, before evaluating Fetuin-A as a biomarker or pharmacological target, an understanding of Fetuin-A variability throughout the life cycle is essential. This manuscript reviews the current body of knowledge surrounding Fetuin-A throughout the life cycle and discuss challenges to studying Fetuin-A.
AB - Fetuin-A is a multifunctional protein which inhibits ectopic calcification and insulin receptor phosphorylation. It may also promote insulin resistance by activation of toll-like receptor 4 pro-inflammatory cascade. Increased levels of Fetuin-A have been associated with obesity and related comorbidities such as type 2 diabetes and cardiovascular disease, therefore, it has been suggested as a potential therapeutic target for intervention. However, in addition to its role in disease pathophysiology, Fetuin-A is also important for growth and development. Thus, before evaluating Fetuin-A as a biomarker or pharmacological target, an understanding of Fetuin-A variability throughout the life cycle is essential. This manuscript reviews the current body of knowledge surrounding Fetuin-A throughout the life cycle and discuss challenges to studying Fetuin-A.
KW - AHSG
KW - Alpha2-Heremans Schmid glycoprotein
KW - Fetuin-A
UR - http://www.scopus.com/inward/record.url?scp=84953321284&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84953321284&partnerID=8YFLogxK
U2 - 10.1016/j.biochi.2015.12.016
DO - 10.1016/j.biochi.2015.12.016
M3 - Review article
C2 - 26740309
AN - SCOPUS:84953321284
SN - 0300-9084
VL - 124
SP - 141
EP - 149
JO - Biochimie
JF - Biochimie
ER -